In mammals, erythropoietin (EPO), produced in the kidney, is essential for bone marrow
erythropoiesis, and hypoxia induction of EPO production provides for the important …

Through their oxygen delivery function, red blood cells are pivotal to the healthy existence of
all vertebrate organisms. These cells are required during all stages of life—embryonic, fetal …

More than 80% of patients with the refractory anemia with ring sideroblasts subtype of
myelodysplastic syndrome (MDS) have mutations in Splicing Factor 3B, Subunit 1 (SF3B1) …

Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage
by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting …

Erythropoietin (EPO) stimulates proliferation of early-stage erythrocyte precursors and is
widely used for the treatment of chronic anemia. However, several types of EPO-resistant …

The nucleolytic activity of animal Argonaute proteins is deeply conserved, despite its having
no obvious role in microRNA-directed gene regulation. In mice, Ago2 (also known as Eif2c2) …

Hematologic parameters are important markers of disease in human and veterinary
medicine. Biomedical research has benefited from mouse models that recapitulate such …

Extracellular proteins bound to cell-surface receptors can change nuclear gene expression
patterns in minutes, with far-reaching consequences for development, cell growth and …

This article reviews the regulation of production of RBCs at several levels. We focus on the
regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids …

Erythroid cells undergo enucleation and the removal of organelles during terminal
differentiation,,. Although autophagy has been suggested to mediate the elimination of …