Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …

Alzheimer's disease (AD) is an immutable neurodegenerative disease featured by the two
hallmark brain pathologies that are the extracellular amyloid ß (Aß) and intraneuronal tau …

Oxidative stress has been associated with normal aging and Alzheimer's disease (AD).
However, little is known about oxidative stress in mild cognitive impairment (MCI) patients …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes
progressive cognitive decline. The majority of AD cases are sporadic and late-onset (> 65 …

Humans have exceptionally long lifespans compared with other mammals. However, our
longevity evolved when our ancestors had two copies of the apolipoprotein E (APOE) ɛ4 …

OBJECTIVE: To obtain a better insight into the effect of the epsilon (e) 4 allele of the
apolipoprotein E gene (APOE) on the risk of late onset Alzheimer's disease (LOAD), and …

Background: Obstructive sleep apnea (OSA) in children is associated with severity-
dependent changes in neurocognitive functioning. However, the severity of OSA accounts …

Sphingolipids (SPLs) represent a highly diverse and structurally complex lipid class. The
discussion of SPL metabolism-related issues is of importance in understanding the …

OBJECTIVE: There are evidence suggesting that APOE-ɛ4 allele play an important role in
the pathogenesis of Alzheimer's disease (AD) by reducing peripheral levels and activities of …

Background: Alzheimer's disease is a chronic disease characterized by a progressive
decline in mental abilities and quality of life alongside behavioral abnormalities associated …