Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …

The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

We report genomic analysis of 300 meningiomas, the most common primary brain tumors,
leading to the discovery of mutations in TRAF7, a proapoptotic E3 ubiquitin ligase, in nearly …

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …

Over the last decades, the cancer survival rate has increased due to personalized therapies,
the discovery of targeted therapeutics and novel biological agents, and the application of …

Hedgehog protein signals mediate tissue patterning and maintenance by binding to and
inactivating their common receptor Patched, a 12-transmembrane protein that otherwise …

Concise, clearly written, and vibrantly illustrated, Langman's Medical Embryology, 15th
Edition, makes complex embryology concepts approachable to help you build the clinical …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Since their isolation in the early 1990s, members of the Hedgehog family of intercellular
signaling proteins have come to be recognized as key mediators of many fundamental …