The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Forty years ago, a simple model of allosteric mechanisms (indirect interactions between
distinct sites), used initially to explain feedback-inhibited enzymes, was presented by …

Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central
nervous system and function by opening a transmembrane ion channel upon binding of …

Abstract AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic
glutamate receptors mediate fast excitatory neurotransmission throughout the central …

AMPA receptors mediate fast excitatory neurotransmission in the mammalian brain and
transduce the binding of presynaptically released glutamate to the opening of a …

At synapses throughout the brain and spinal cord, the amino-acid glutamate is the major
excitatory neurotransmitter. During evolution, a family of glutamate-receptor ion channels …

Glutamate receptor ion channels mediate excitatory responses at the majority of CNS
synapses. They are the only ligand-gated ion channels for which multiple high-resolution …

NMDA receptors (NMDARs) are glutamate-gated cation channels with high calcium
permeability that play important roles in many aspects of the biology of higher organisms …

Ionotropic glutamate receptors mediate fast excitatory synaptic transmission in the central
nervous system,. Their modulation is believed to affect learning and memory, and their …

Ionotropic glutamate receptors are ligand-gated ion channels that mediate rapid information
transfer at most excitatory synapses in the brain. Crystal structures are now available for the …