Early-life environment influence on late-onset Alzheimer's disease

T Gauvrit, H Benderradji, L Buée, D Blum… - Frontiers in cell and …, 2022 - frontiersin.org
With the expand of the population's average age, the incidence of neurodegenerative
disorders has dramatically increased over the last decades. Alzheimer disease (AD) which …

Melatonin: a potential candidate for the treatment of experimental and clinical perinatal asphyxia

R Pluta, W Furmaga-Jabłońska, S Januszewski… - Molecules, 2023 - mdpi.com
Perinatal asphyxia is considered to be one of the major causes of brain neurodegeneration
in full-term newborns. The worst consequence of perinatal asphyxia is neurodegenerative …

Obstructive sleep apnea decreases central nervous system–derived proteins in the cerebrospinal fluid

YES Ju, MB Finn, CL Sutphen, EM Herries… - Annals of …, 2016 - Wiley Online Library
We hypothesized that one mechanism underlying the association between obstructive sleep
apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity …

Development of a reliable method based on ultra-performance liquid chromatography coupled to tandem mass spectrometry to measure thiol-associated oxidative …

J Escobar, Á Sánchez-Illana, J Kuligowski… - … of pharmaceutical and …, 2016 - Elsevier
The aminothiols are biological compounds with numerous vital functions. One of the most
relevant is their role as antioxidant systems. The reduced to oxidized ratios are extremely …

Hypoxic-Ischemic Brain Injury after Perinatal Asphyxia as a Possible Factor in the Pathology of Alzheimer's Disease

A Tarkowska - Exon Publications, 2021 - exonpublications.com
Perinatal asphyxia is a common pathological condition occurring worldwide in
approximately 4 million newborns annually. The result of this phenomenon is multi-organ …

Splanchnic oxygen saturation during reoxygenation with 21% or 100% O2 in newborn piglets

BM Dotinga, R Solberg, OD Saugstad, AF Bos… - Pediatric …, 2022 - nature.com
Background Increasing evidence recognizes the harm of excess oxygen to lungs, eyes, and
brain of preterm infants, but not yet to the intestine. We assessed changes in splanchnic …

Alzheimer's Disease Associated Presenilin 1 and 2 Genes Dysregulation in Neonatal Lymphocytes Following Perinatal Asphyxia

A Tarkowska, W Furmaga-Jabłońska, J Bogucki… - International Journal of …, 2021 - mdpi.com
Perinatal asphyxia is mainly a brain disease leading to the development of
neurodegeneration, in which a number of peripheral lesions have been identified; however …

Assessing nuclear versus mitochondrial cell-free dna (cfdna) by qrt-pcr and droplet digital pcr using a piglet model of perinatal asphyxia

M Bitenc, B Grebstad Tune, M Melheim… - Molecular Biology …, 2023 - Springer
Background Since the discovery more than half a century ago, cell-free DNA (cfDNA) has
become an attractive objective in multiple diagnostic, prognostic, and monitoring settings …

Hypothermia after perinatal asphyxia does not affect genes responsible for amyloid production in neonatal peripheral lymphocytes

A Tarkowska, W Furmaga-Jabłońska, J Bogucki… - Journal of Clinical …, 2022 - mdpi.com
In this study, the expression of the genes of the amyloid protein precursor, β-secretase,
presenilin 1 and 2 by RT-PCR in the lymphocytes of newborns after perinatal asphyxia and …

Temporal patterns of circulating cell-free DNA (cfDNA) in a newborn piglet model of perinatal asphyxia

S Manueldas, T Benterud, CS Rueegg, HT Garberg… - PloS one, 2018 - journals.plos.org
Perinatal asphyxia is a severe medical condition resulting from oxygen deficiency (hypoxia)
at the time of birth, causing worldwide approximately 680,000 newborn deaths every year …