The TGF-β signaling pathway plays a crucial role in several key aspects of development and
tissue homeostasis. TGF-β ligands and their mediators have been shown to be important …

Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that has the
potential to affect vision, and can even be fatal in some children. While the tumor can be …

The first steps towards establishing xenografts in zebrafish embryos were performed by Lee
et al., 2005 and Haldi et al., 2006, paving the way for studying human cancers using this …

The activation of hepatic stellate cells (HSCs) and liver fibrosis in the peri-tumoral tissue
contributes to the progression of hepatocellular carcinoma (HCC). However, the …

Spheroidal cancer cell cultures have been used to enrich cancer stem cells (CSC), which
are thought to contribute to important clinical features of tumors. This study aimed to map the …

Background The conditional reprogramming cell culture method was developed to facilitate
growth of senescence-prone normal and neoplastic epithelial cells, and involves co-culture …

Background Asthma is a chronic airway disorder with a hallmark feature of airflow
obstruction that associated with the remodeling and inflammation in the airway wall …

Simple Summary Cancer stands as the leading cause of death among children and
adolescents in the United States. Some of these pediatric cancers are highly aggressive and …

Upstream stimuli for myofibroblast activation are of considerable interest for understanding
the mechanisms underlying renal fibrosis. Activin B, a member of the TGF‐β family, exists as …

Background Cancer stem cells form a rare cell population in tumors that contributes to
metastasis, recurrence and chemoresistance in cancer patients. Circular RNAs (circRNAs) …