Recent advances in therapeutic targets identification and development of treatment strategies towards Pseudomonas aeruginosa infections
DRA Sanya, D Onésime, G Vizzarro, N Jacquier - BMC microbiology, 2023 - Springer
The opportunistic human pathogen Pseudomonas aeruginosa is the causal agent of a wide
variety of infections. This non-fermentative Gram-negative bacillus can colonize zones …
variety of infections. This non-fermentative Gram-negative bacillus can colonize zones …
Recent advances in monoclonal antibody-based approaches in the management of bacterial sepsis
K Kharga, L Kumar, SKS Patel - Biomedicines, 2023 - mdpi.com
Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory
response to an infectious agent and its antigens. Immune cell activation against the antigens …
response to an infectious agent and its antigens. Immune cell activation against the antigens …
Current promising strategies against antibiotic-resistant bacterial infections
Infections caused by antibiotic-resistant bacteria (ARB) are one of the major global health
challenges of our time. In addition to developing new antibiotics to combat ARB, sensitizing …
challenges of our time. In addition to developing new antibiotics to combat ARB, sensitizing …
Glycoconjugate vaccines against antimicrobial resistant pathogens
C Sorieul, M Dolce, MR Romano, J Codée… - Expert Review of …, 2023 - Taylor & Francis
Introduction Antimicrobial resistance (AMR) is responsible for the death of millions
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …
Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa
X Wang, C Liu, N Rcheulishvili, D Papukashvili, F Xie… - npj Vaccines, 2023 - nature.com
Pseudomonas aeruginosa (PA) is a leading cause of hospital-acquired and ventilator-
associated pneumonia. The multidrug-resistance (MDR) rate of PA is increasing making the …
associated pneumonia. The multidrug-resistance (MDR) rate of PA is increasing making the …
Pseudomonas aeruginosa breaches respiratory epithelia through goblet cell invasion in a microtissue model
AL Swart, BJ Laventie, R Sütterlin, T Junne… - Nature …, 2024 - nature.com
Pseudomonas aeruginosa, a leading cause of severe hospital-acquired pneumonia, causes
infections with up to 50% mortality rates in mechanically ventilated patients. Despite some …
infections with up to 50% mortality rates in mechanically ventilated patients. Despite some …
Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa
A Simonis, C Kreer, A Albus, K Rox, B Yuan… - Cell, 2023 - cell.com
Drug-resistant Pseudomonas aeruginosa (PA) poses an emerging threat to human health
with urgent need for alternative therapeutic approaches. Here, we deciphered the B cell and …
with urgent need for alternative therapeutic approaches. Here, we deciphered the B cell and …
Hit 'em Where It Hurts: Gram-Negative Bacterial Lipopolysaccharide as a Vaccine Target
AS Cross - Microbiology and Molecular Biology Reviews, 2023 - Am Soc Microbiol
Infections with antimicrobial-resistant (AMR) bacteria pose an increasing threat to the ability
to perform surgical procedures, organ transplantation, and treat cancer among many other …
to perform surgical procedures, organ transplantation, and treat cancer among many other …
How Three Self-Secreted Biofilm Exopolysaccharides of Pseudomonas aeruginosa, Psl, Pel, and Alginate, Can Each Be Exploited for Antibiotic Adjuvant Effects in …
J Chung, S Eisha, S Park, AJ Morris… - International Journal of …, 2023 - mdpi.com
In cystic fibrosis (CF), pulmonary infection with Pseudomonas aeruginosa is a cause of
increased morbidity and mortality, especially in patients for whom infection becomes chronic …
increased morbidity and mortality, especially in patients for whom infection becomes chronic …
Therapeutic antibodies in medicine
P Sharma, RV Joshi, R Pritchard, K Xu, MA Eicher - Molecules, 2023 - mdpi.com
Antibody engineering has developed into a wide-reaching field, impacting a multitude of
industries, most notably healthcare and diagnostics. The seminal work on developing the …
industries, most notably healthcare and diagnostics. The seminal work on developing the …