The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting
CS Von Bartheld, J Bahney… - Journal of …, 2016 - Wiley Online Library
For half a century, the human brain was believed to contain about 100 billion neurons and
one trillion glial cells, with a glia: neuron ratio of 10: 1. A new counting method, the isotropic …
one trillion glial cells, with a glia: neuron ratio of 10: 1. A new counting method, the isotropic …
The locus coeruleus: essential for maintaining cognitive function and the aging brain
Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …
hippocampal regions influence cognition. However, brainstem regions play essential …
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline
Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …
The role of noradrenaline in cognition and cognitive disorders
Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …
forebrain originating from the locus coeruleus, acting through alpha and beta …
[HTML][HTML] Egocentric and allocentric spatial reference frames in aging: A systematic review
Aging affects many aspects of everyday living, such as autonomy, security and quality of life.
Among all, spatial memory and spatial navigation show a gradual but noticeable decline, as …
Among all, spatial memory and spatial navigation show a gradual but noticeable decline, as …
The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer's disease
Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …
The pathological process underlying Alzheimer's disease in individuals under thirty
H Braak, K Del Tredici - Acta neuropathologica, 2011 - Springer
Brains of 42 individuals between the ages of 4 and 29 were examined with antibodies (AT8,
4G8) and silver stains for the presence of intraneuronal and extracellular protein aggregates …
4G8) and silver stains for the presence of intraneuronal and extracellular protein aggregates …
[HTML][HTML] Pupil size signals mental effort deployed during multiple object tracking and predicts brain activity in the dorsal attention network and the locus coeruleus
Attentional effort relates to the allocation of limited-capacity attentional resources to meet
current task demands and involves the activation of top-down attentional systems in the …
current task demands and involves the activation of top-down attentional systems in the …
The affective neuroscience of aging
M Mather - Annual review of psychology, 2016 - annualreviews.org
Although aging is associated with clear declines in physical and cognitive processes,
emotional functioning fares relatively well. Consistent with this behavioral profile, two core …
emotional functioning fares relatively well. Consistent with this behavioral profile, two core …
Neocortical glial cell numbers in human brains
DP Pelvig, H Pakkenberg, AK Stark, B Pakkenberg - Neurobiology of aging, 2008 - Elsevier
Stereological cell counting was applied to post-mortem neocortices of human brains from 31
normal individuals, age 18–93 years, 18 females (average age 65 years, range 18–93) and …
normal individuals, age 18–93 years, 18 females (average age 65 years, range 18–93) and …