Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein
ligase that targets different substrates for ubiquitylation and therefore regulates a variety of …

Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that plays a significant
role in mitotic progression and cellular responses to DNA damage. While traditionally …

Mammalian oocytes are arrested at the prophase of the first meiotic division for months and
even years, depending on species. Meiotic resumption of fully grown oocytes requires …

During fertilization, an egg and a sperm fuse to form a new embryo. Eggs develop from
oocytes in a process called meiosis. Meiosis in human oocytes is highly error-prone,, and …

Simple Summary GBM is a highly heterogeneous tumor owing to incredible cellular plasticity
and adaptation to hypoxia, nutrient availability and therapy. This plasticity is in part due to …

Mammalian oogenesis features reliance on the mRNAs produced and stored during early
growth phase. These are essential for producing an oocyte competent to undergo meiotic …

Oocyte meiosis is a specialized cell cycle that gives rise to fertilizable haploid gametes and
is precisely controlled in various dimensions. We recently found that E3 ubiquitin ligase …

Mitosis is controlled by a subtle balance between kinase and phosphatase activities that
involve the master mitotic kinase cyclin-B–Cdk1 and its antagonizing protein phosphatase …

Cyclins associate with cyclin-dependent serine/threonine kinase 1 (CDK1) to generate the M
phase-promoting factor (MPF) activity essential for progression through mitosis and meiosis …

In metazoans that undergo sexual reproduction, genomic inheritance is ensured by two
distinct types of cell cycle, mitosis and meiosis. Mitosis maintains the genomic ploidy in …