Tailoring mRNA vaccine to balance innate/adaptive immune response
S Linares-Fernández, C Lacroix, JY Exposito… - Trends in molecular …, 2020 - cell.com
mRNA vaccine platforms present numerous advantages, such as versatility, rapid
production, and induction of cellular and humoral responses. Moreover, mRNAs have …
production, and induction of cellular and humoral responses. Moreover, mRNAs have …
Synonymous but not silent: the codon usage code for gene expression and protein folding
Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …
Although synonymous mutations were previously thought to be silent, a large body of …
Protein structure and sequence reanalysis of 2019-nCoV genome refutes snakes as its intermediate host and the unique similarity between its spike protein insertions …
As the infection of 2019-nCoV coronavirus is quickly developing into a global pneumonia
epidemic, the careful analysis of its transmission and cellular mechanisms is sorely needed …
epidemic, the careful analysis of its transmission and cellular mechanisms is sorely needed …
Codon-specific Ramachandran plots show amino acid backbone conformation depends on identity of the translated codon
Synonymous codons translate into chemically identical amino acids. Once considered
inconsequential to the formation of the protein product, there is evidence to suggest that …
inconsequential to the formation of the protein product, there is evidence to suggest that …
Causes and consequences of purifying selection on SARS-CoV-2
Owing to a lag between a deleterious mutation's appearance and its selective removal, gold-
standard methods for mutation rate estimation assume no meaningful loss of mutations …
standard methods for mutation rate estimation assume no meaningful loss of mutations …
mRNA-based therapeutics in cancer treatment
H Sun, Y Zhang, G Wang, W Yang, Y Xu - Pharmaceutics, 2023 - mdpi.com
Over the past two decades, significant technological innovations have led to messenger
RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic …
RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic …
[HTML][HTML] Codon-based indices for modeling gene expression and transcript evolution
S Bahiri-Elitzur, T Tuller - Computational and Structural Biotechnology …, 2021 - Elsevier
Codon usage bias (CUB) refers to the phenomena that synonymous codons are used in
different frequencies in most genes and organisms. The general assumption is that codon …
different frequencies in most genes and organisms. The general assumption is that codon …
In silico methods for predicting functional synonymous variants
Single nucleotide variants (SNVs) contribute to human genomic diversity. Synonymous
SNVs are previously considered to be “silent,” but mounting evidence has revealed that …
SNVs are previously considered to be “silent,” but mounting evidence has revealed that …
Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design
As the SARS-CoV-2 pandemic is rapidly progressing, the need for the development of an
effective vaccine is critical. A promising approach for vaccine development is to generate …
effective vaccine is critical. A promising approach for vaccine development is to generate …
Nucleotide composition and codon usage across viruses and their respective hosts
The genetic material of the three domains of life (Bacteria, Archaea, and Eukaryota) is
always double-stranded DNA, and their GC content (molar content of guanine plus cytosine) …
always double-stranded DNA, and their GC content (molar content of guanine plus cytosine) …