With 1.4 million deaths and 8.7 million new cases in 2011, tuberculosis (TB) remains a
global health care problem and together with HIV and Malaria represents one of the three …

With the development and regulatory approval of immune checkpoint inhibitors and adoptive
cell therapies, cancer immunotherapy has undergone a profound transformation over the …

Improved vaccines capable of promoting long-term cellular immunity are urgently required
for a number of diseases that remain global health problems. In the present study, we …

The concept of therapeutic cancer vaccines is based on the activation of the immune system
against tumor cells after the presentation of tumor antigens. Nanoparticles (NPs) have …

The contributions of different subsets of memory CD8+ T cells to recall responses at mucosal
sites of infection are poorly understood. Here, we analyzed the CD8+ T cell recall responses …

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The rapid effector functions and tissue heterogeneity of memory T cells facilitate protective
immunity, but they can also promote immunopathology in antiviral immunity, autoimmunity …

In most cases, a successful vaccine must induce an immune response that is better than the
response invoked by natural infection. Vaccines are still unavailable for several bacterial …

We previously reported results of a phase II trial in which recombinant MAGE-A3 protein was
administered with or without adjuvant AS02B to 18 non-small-cell lung cancer (NSCLC) …

The persistence of central memory CD4+ T cells (TCM cells) is a major correlate of
immunological protection in HIV/AIDS, as the rate of TCM cell decline predicts HIV disease …