The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508
(ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane …

Abstract Coronavirus disease 2019 (COVID-19) has caused thousands of deaths worldwide
and has become an urgent public health concern. The extraordinary interhuman …

Of the 20 common amino acids, 18 are encoded by multiple synonymous codons. These
synonymous codons are not redundant; in fact, all of codons contribute substantially to …

Translation of consecutive prolines causes ribosome stalling, which is alleviated but cannot
be fully compensated by the elongation factor P. However, the presence of polyproline …

Inherited and somatic rare diseases result from> 200,000 genetic variants leading to loss-or
gain-of-toxic function, often caused by protein misfolding. Many of these misfolded variants …

Biological production of fatty acid (FA)-derived products has gained increasing attention to
replace petroleum-based fuels and chemicals. FA biosynthesis is highly regulated, and …

When production of bispecific antibodies requires the co-expression and assembly of three
or four polypeptide chains, low expression of one chain can significantly limit assembly and …

By using fluorescence imaging, we provide a time-resolved single-cell view on coupled
defects in transcription, translation, and growth during expression of heterologous …

Due to the redundancy of the genetic code most amino acids are encoded by multiple
synonymous codons. It has been proposed that a biased frequency of synonymous codons …

Viruses are small infectious agents that replicate only inside the living cells of other
organisms and comprise approximately 94% of the nucleic acid-containing particles in the …