Glutathione S-transferases (GSTs) are a major class of phase II metabolic enzymes. Besides
their essential role in detoxification, GSTs also exert diverse biological activities in the …

As the development of new antibiotics lags far behind the emergence of drug‐resistant
bacteria, alternative strategies to resolve this dilemma are urgently required. Antibody‐drug …

Antimicrobial resistant (AMR) bacteria are emerging and spreading globally, threatening our
ability to treat common infectious diseases. The development of new classes of antibiotics …

Four bipyridine-type ligands variably derivatized with two bioactive groups (taken from
ethacrynic acid, flurbiprofen, biotin, and benzylpenicillin) were prepared via sequential …

The dynamic and versatile group of enzymes referred to as glutathione S-transferases
(GSTs) play diverse roles in cellular detoxification, safeguarding hosts from oxidative …

In comparison with RuII-arene compounds, the medicinal potential of homologous RuII-tpm
compounds [tpm= tris (pyrazolyl) methane] is underexplored. Pyridine, 4-pyridinemethanol …

Ethacrynic acid (EA, Edecrin) is a well-known diuretic drug used in the treatment of high
blood pressure and the swelling caused by diseases such as congestive heart failure, liver …

Tris (pyrazolyl) methane (tpm), 2, 2, 2-tris (pyrazolyl) ethanol (tpmOH) and its esterification
derivatives with ibuprofen and flurbiprofen (tpmIBU and tpmFLU) were used as ligands to …

Bipyridines and azaarenes are an important class of ligands that impart unique and tunable
properties to transition metal complexes and catalysts. While some derivatives are …

Platinum (Pt) drugs, including cisplatin, are widely used for the treatment of solid tumors.
Despite the clinical success, side effects and occurrence of resistance represent major …