Awareness and current knowledge of epilepsy

AU Khan, M Akram, M Daniyal, N Akhter, M Riaz… - Metabolic Brain …, 2020 - Springer
Epilepsy is a severe neural disorder that affects approximately fifty million individuals
globally. Despite the fact that for most of the people with epilepsy, convulsions are better …

5-Hydroxytryptamine2A/2C receptors of nucleus raphe magnus and gigantocellularis/paragigantocellularis pars α reticular nuclei modulate the unconditioned fear …

R de Oliveira, RC de Oliveira… - Behavioural Brain …, 2017 - Elsevier
The electrical stimulation of the dorsolateral columns of the periaquedutal grey matter
(dlPAG) or deep layers of the superior colliculus (dlSC) evokes defensive behaviours …

[HTML][HTML] GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal …

M Mendonça-dos-Santos, TCT Gonçalves… - Scientific Reports, 2024 - nature.com
We investigated the participation of the nucleus of the tractus solitarius (NTS) in tonic‒clonic
seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS …

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5‐HT2A and 5‐HT2C serotonergic receptors in post‐ictal …

RL de Freitas, RC de Oliveira, R de Oliveira… - Synapse, 2014 - Wiley Online Library
The periaqueductal gray matter (PAG) consists in a brainstem structure rich in 5‐
hydroxytryptamine (5‐HT) inputs related to the modulation of pain. The involvement of each …

µ1‐Opioid receptors in the dorsomedial and ventrolateral columns of the periaqueductal grey matter are critical for the enhancement of post‐ictal antinociception

RL de Freitas, P Medeiros, AU Khan, NC Coimbra - Synapse, 2016 - Wiley Online Library
Generalised tonic and tonic–clonic seizures are followed by significant increase in
nociceptive thresholds in both laboratory animals and humans. The endogenous opioid …

Neuroanatomical and neuropharmacological approaches to postictal antinociception‐related prosencephalic neurons: the role of muscarinic and nicotinic cholinergic …

RL de Freitas, LI Bolognesi, A Twardowschy… - Brain and …, 2013 - Wiley Online Library
Several studies have suggested the involvement of the hippocampus in the elaboration of
epilepsy. There is evidence that suggests the hippocampus plays an important role in the …

Endogenous opioid peptide-mediated neurotransmission in central and pericentral nuclei of the inferior colliculus recruits μ1-opioid receptor to modulate post-ictal …

TT Felippotti, RL de Freitas, NC Coimbra - Neuropeptides, 2012 - Elsevier
BACKGROUND: The aim of the present work was to investigate the involvement of the μ1-
endogenous opioid peptide receptor-mediated system in post-ictal antinociception …

[HTML][HTML] Neurotoxic lesions of the pedunculopontine tegmental nucleus impair the elaboration of postictal antinociception

RC de Oliveira, R de Oliveira, LL Falconi-Sobrinho… - Physiology & …, 2018 - Elsevier
Generalised tonic-clonic seizures, generated by abnormal neuronal hyper-activity, cause a
significant and long-lasting increase in the nociceptive threshold. The pedunculopontine …

Intrinsic connections within the pedunculopontine tegmental nucleus are critical to the elaboration of post‐ictal antinociception

EC Mazzei‐Silva, RC de Oliveira, TDA Garcia… - Synapse, 2014 - Wiley Online Library
This study investigated the intrinsic connections of a key‐structure of the endogenous pain
inhibitory system, the pedunculopontine tegmental nucleus (PPTN), in post‐ictal …

The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT2A and 5-HT2C serotonergic receptors in post-ictal …

RL Freitas, RC Oliveira, R Oliveira… - …, 2014 - search.ebscohost.com
ABSTRACT The periaqueductal gray matter (PAG) consists in a brainstem structure rich in 5-
hydroxytryptamine (5-HT) inputs related to the modulation of pain. The involvement of each …