[HTML][HTML] The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
Acute lymphoblastic leukaemia
H Inaba, M Greaves, CG Mullighan - The Lancet, 2013 - thelancet.com
Acute lymphoblastic leukaemia occurs in both children and adults but its incidence peaks
between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous …
between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous …
[HTML][HTML] Classification and personalized prognosis in myeloproliferative neoplasms
J Grinfeld, J Nangalia, EJ Baxter… - … England Journal of …, 2018 - Mass Medical Soc
Background Myeloproliferative neoplasms, such as polycythemia vera, essential
thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied …
thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied …
Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group
SC Reshmi, RC Harvey, KG Roberts… - Blood, The Journal …, 2017 - ashpublications.org
Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk
subtype characterized by genomic alterations that activate cytokine receptor and kinase …
subtype characterized by genomic alterations that activate cytokine receptor and kinase …
[HTML][HTML] JAKs and STATs in immunity, immunodeficiency, and cancer
JAKs and STATs in Immunity, Immunodeficiency, and Cancer | NEJM Skip to main content
NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a …
NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a …
Philadelphia chromosome–like acute lymphoblastic leukemia
Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as
BCR-ABL1–like ALL, is a high-risk subset with a gene expression profile that shares …
BCR-ABL1–like ALL, is a high-risk subset with a gene expression profile that shares …
Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?
CH Pui, CG Mullighan, WE Evans… - Blood, The Journal of …, 2012 - ashpublications.org
Improved supportive care, more precise risk stratification, and personalized chemotherapy
based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and …
based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and …
The molecular regulation of Janus kinase (JAK) activation
The JAK (Janus kinase) family members serve essential roles as the intracellular signalling
effectors of cytokine receptors. This family, comprising JAK1, JAK2, JAK3 and TYK2 (tyrosine …
effectors of cytokine receptors. This family, comprising JAK1, JAK2, JAK3 and TYK2 (tyrosine …
[HTML][HTML] The regulation of JAKs in cytokine signaling and its breakdown in disease
HM Hammarén, AT Virtanen, J Raivola, O Silvennoinen - Cytokine, 2019 - Elsevier
The JAK–STAT signal transduction pathway is responsible for mediating signals of over fifty
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …
Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine
SP Hunger, CG Mullighan - Blood, The Journal of the American …, 2015 - ashpublications.org
Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a
leading cause of cancer death in the young. In the last decade, microarray and sequencing …
leading cause of cancer death in the young. In the last decade, microarray and sequencing …