[HTML][HTML] Neuropsychiatric disorders in Cushing's syndrome

R Pivonello, C Simeoli, MC De Martino… - Frontiers in …, 2015 - frontiersin.org
Endogenous Cushing's syndrome (CS), a rare endocrine disorder characterized by cortisol
hypersecretion, is associated with psychiatric and neurocognitive disorders. Major …

[HTML][HTML] Glucocorticoids and cognitive function: a walkthrough in endogenous and exogenous alterations

D De Alcubierre, D Ferrari, G Mauro, AM Isidori… - Journal of …, 2023 - Springer
Purpose The hypothalamic–pituitary–adrenal (HPA) axis exerts many actions on the central
nervous system (CNS) aside from stress regulation. Glucocorticoids (GCs) play an important …

Mechanisms in endocrinology: Cushing's syndrome causes irreversible effects on the human brain: a systematic review of structural and functional magnetic …

CD Andela, FM van Haalen… - European Journal of …, 2015 - academic.oup.com
Background Cushing's syndrome (CS) is characterized by excessive exposure to cortisol,
and is associated with both metabolic and behavioral abnormalities. Symptoms improve …

Long‐term effects of glucocorticoid excess on the brain

AJ Dekkers, JM Amaya… - Journal of …, 2022 - Wiley Online Library
The metabolic and cardiovascular clinical manifestations in patients with Cushing's
syndrome (CS) are generally well known. However, recent studies have broadened the …

Long-Term Consequences of Cushing Syndrome: A Systematic Literature Review

S Puglisi, AME Perini, C Botto, F Oliva… - The Journal of Clinical …, 2024 - academic.oup.com
It is held that the condition of endogenous chronic hypersecretion of cortisol (Cushing
syndrome, CS), causes several comorbidities, including cardiovascular and metabolic …

Psychiatric and neurocognitive consequences of endogenous hypercortisolism

M Piasecka, E Papakokkinou, E Valassi… - Journal of internal …, 2020 - Wiley Online Library
Psychiatric and neurocognitive symptoms due to hypercortisolism were already described
by Harvey Cushing in his original paper on patients with Cushing's syndrome (CS) …

Smaller grey matter volumes in the anterior cingulate cortex and greater cerebellar volumes in patients with long-term remission of Cushing's disease: a case–control …

CD Andela, SJA van der Werff… - European Journal of …, 2013 - academic.oup.com
Objective Patients with long-term remission of Cushing's disease (CD) have persistent
psychological and cognitive impairments. It is unknown whether, and to what extent, these …

[HTML][HTML] Quality of life in patients with Cushing's disease

A Santos, E Resmini, MA Martínez Momblán… - Frontiers in …, 2019 - frontiersin.org
Cushing's disease (and by extension, Cushing's syndrome) is a rare disease due to a
chronic cortisol excess, which usually has an important impact on quality of life (QoL). It can …

White matter alterations in the brains of patients with active, remitted, and cured Cushing syndrome: a DTI study

P Pires, A Santos, Y Vives-Gilabert… - American Journal …, 2015 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Cushing syndrome appears after chronic exposure to
elevated glucocorticoid levels. Cortisol excess may alter white matter microstructure. Our …

MANAGEMENT OF ENDOCRINE DISEASE: Cushing's syndrome: a structured short-and long-term management plan for patients in remission

O Ragnarsson, G Johannsson - European journal of …, 2013 - academic.oup.com
One hundred years have passed since Harvey Williams Cushing presented the first patient
with the syndrome that bears his name. In patients with Cushing's syndrome (CS), body …