Recommendations for good practice in MS-based lipidomics
In the last 2 decades, lipidomics has become one of the fastest expanding scientific
disciplines in biomedical research. With an increasing number of new research groups to …
disciplines in biomedical research. With an increasing number of new research groups to …
Advanced tandem mass spectrometry in metabolomics and lipidomics—methods and applications
S Heiles - Analytical and Bioanalytical Chemistry, 2021 - Springer
Metabolomics and lipidomics are new drivers of the omics era as molecular signatures and
selected analytes allow phenotypic characterization and serve as biomarkers, respectively …
selected analytes allow phenotypic characterization and serve as biomarkers, respectively …
Deep-profiling of phospholipidome via rapid orthogonal separations and isomer-resolved mass spectrometry
A lipidome comprises thousands of lipid species, many of which are isomers and isobars.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …
Deep-lipidotyping by mass spectrometry: recent technical advances and applications
In-depth structural characterization of lipids is an essential component of lipidomics. There
has been a rapid expansion of mass spectrometry methods that are capable of resolving …
has been a rapid expansion of mass spectrometry methods that are capable of resolving …
Mass spectrometry imaging of lipids with isomer resolution using high-pressure ozone-induced dissociation
Mass spectrometry imaging (MSI) of lipids within tissues has significant potential for both
biomolecular discovery and histopathological applications. Conventional MSI technologies …
biomolecular discovery and histopathological applications. Conventional MSI technologies …
Relative quantification of lipid isomers in imaging mass spectrometry using gas-phase charge inversion ion/ion reactions and infrared multiphoton dissociation
Accurate structural identification of lipids in imaging mass spectrometry is critical to properly
contextualizing spatial distributions with tissue biochemistry. Gas-phase charge inversion …
contextualizing spatial distributions with tissue biochemistry. Gas-phase charge inversion …
Voltage-controlled divergent cascade of electrochemical reactions for characterization of lipids at multiple isomer levels using mass spectrometry
Cascading divergent reactions in a single system is highly desirable for their intrinsic
efficiency and potential to achieve multilevel structural characterization of complex …
efficiency and potential to achieve multilevel structural characterization of complex …
Lipid mass tags via aziridination for probing unsaturated lipid isomers and accurate relative quantification
Knowing concentrations of lipids is essential for understanding their physiological functions
and discovering new disease biomarkers. However, it is highly challenging to accurately …
and discovering new disease biomarkers. However, it is highly challenging to accurately …
Perspective on emerging mass spectrometry technologies for comprehensive lipid structural elucidation
JR Bonney, BM Prentice - Analytical chemistry, 2021 - ACS Publications
Lipids and metabolites are of interest in many clinical and research settings because it is the
metabolome that is increasingly recognized as a more dynamic and sensitive molecular …
metabolome that is increasingly recognized as a more dynamic and sensitive molecular …
Development of an efficient on-tissue epoxidation reaction mediated by urea hydrogen peroxide for MALDI MS/MS imaging of lipid C═ C location isomers
Unsaturated lipids containing different numbers and locations of C═ C bonds are
significantly associated with a variety of cellular and metabolic functions. Although matrix …
significantly associated with a variety of cellular and metabolic functions. Although matrix …