Brain endothelial cell junctions after cerebral hemorrhage: changes, mechanisms and therapeutic targets

RF Keep, AV Andjelkovic, J Xiang… - Journal of Cerebral …, 2018 - journals.sagepub.com
Vascular disruption is the underlying cause of cerebral hemorrhage, including intracerebral,
subarachnoid and intraventricular hemorrhage. The disease etiology also involves cerebral …

A new perspective on cerebrospinal fluid dynamics after subarachnoid hemorrhage: from normal physiology to pathophysiological changes

Y Fang, L Huang, X Wang, X Si… - Journal of Cerebral …, 2022 - journals.sagepub.com
Knowledge about the dynamic metabolism and function of cerebrospinal fluid (CSF)
physiology has rapidly progressed in recent decades. It has traditionally been suggested …

Autophagy-mediated occludin degradation contributes to blood–brain barrier disruption during ischemia in bEnd. 3 brain endothelial cells and rat ischemic stroke …

KA Kim, D Kim, JH Kim, YJ Shin, ES Kim… - Fluids and Barriers of …, 2020 - Springer
Background The blood–brain barrier (BBB) maintains homeostasis of the brain environment
by tightly regulating the entry of substances from systemic circulation. A breach in the BBB …

Choroid plexus enlargement and allostatic load in schizophrenia

YF Zhou, JC Huang, P Zhang, FM Fan… - Schizophrenia …, 2020 - academic.oup.com
Although schizophrenia is a brain disorder, increasing evidence suggests that there may be
body-wide involvement in this illness. However, direct evidence of brain structures involved …

Immune compartments at the brain's borders in health and neurovascular diseases

JE Goertz, L Garcia-Bonilla, C Iadecola… - Seminars in …, 2023 - Springer
Recent evidence implicates cranial border immune compartments in the meninges, choroid
plexus, circumventricular organs, and skull bone marrow in several neuroinflammatory and …

Challenges for intraventricular hemorrhage research and emerging therapeutic targets

T Garton, Y Hua, J Xiang, G Xi… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Intraventricular hemorrhage (IVH) affects both premature infants and adults. In
both demographics, it has high mortality and morbidity. There is no FDA approved therapy …

AQP1 and AQP4 contribution to cerebrospinal fluid homeostasis

JL Trillo-Contreras, JJ Toledo-Aral, M Echevarría… - Cells, 2019 - mdpi.com
Aquaporin 1 (AQP1), expressed in epithelial cells of the choroid plexus, and aquaporin 4
(AQP4) present in ependymal cells and glia limitants have been proposed to play a …

Macular microvasculature is associated with total cerebral small vessel disease burden in recent single subcortical infarction

WR Kwapong, S Jiang, Y Yan, J Wan… - Frontiers in Aging …, 2022 - frontiersin.org
Purpose To assess the retinal microvasculature, choriocapillaris, and choroidal thickness in
recent single subcortical infarction (RSSI) patients compared with healthy controls. We also …

NLRP3-dependent lipid droplet formation contributes to posthemorrhagic hydrocephalus by increasing the permeability of the blood–cerebrospinal fluid barrier in the …

Z Zhang, P Guo, L Liang, S Jila, X Ru… - … & Molecular Medicine, 2023 - nature.com
Hydrocephalus is a severe complication that can result from intracerebral hemorrhage,
especially if this hemorrhage extends into the ventricles. Our previous study indicated that …

Release of interleukin-10 and neurotrophic factors in the choroid plexus: possible inductors of neurogenesis following copolymer-1 immunization after cerebral …

Y Cruz, EE García, JV Gálvez… - Neural regeneration …, 2018 - journals.lww.com
Abstract Copolymer-1 (Cop-1) is a peptide with immunomodulatory properties, approved by
the Food and Drug Administration of United States in the treatment of multiple sclerosis. Cop …