[HTML][HTML] Tumor-on-a-chip: from bioinspired design to biomedical application

X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

[HTML][HTML] Consensus guidelines for the use and interpretation of angiogenesis assays

P Nowak-Sliwinska, K Alitalo, E Allen, A Anisimov… - Angiogenesis, 2018 - Springer
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

[HTML][HTML] Organs-on-a-chip: a fast track for engineered human tissues in drug development

K Ronaldson-Bouchard, G Vunjak-Novakovic - Cell stem cell, 2018 - cell.com
Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable
modeling of human physiology and disease. The technology has emerged from converging …

[HTML][HTML] Integration of substrate-and flow-derived stresses in endothelial cell mechanobiology

CA Dessalles, C Leclech, A Castagnino… - Communications …, 2021 - nature.com
Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids

VS Shirure, Y Bi, MB Curtis, A Lezia… - Lab on a Chip, 2018 - pubs.rsc.org
Most cancer treatment strategies target cell proliferation, angiogenesis, migration, and
intravasation of tumor cells in an attempt to limit tumor growth and metastasis. An in vitro …

Mechanotransduction in tumor progression: The dark side of the force

F Broders-Bondon, TH Nguyen Ho-Bouldoires… - Journal of Cell …, 2018 - rupress.org
Cancer has been characterized as a genetic disease, associated with mutations that cause
pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the …

[HTML][HTML] Engineering vascularized organoid-on-a-chip models

VS Shirure, CCW Hughes… - Annual Review of …, 2021 - annualreviews.org
Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …

From arteries to capillaries: approaches to engineering human vasculature

S Fleischer, DN Tavakol… - Advanced functional …, 2020 - Wiley Online Library
From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple
scales and cell types. The convergence of bioengineering, materials science, and stem cell …

[HTML][HTML] Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance

J Lim, H Ching, JK Yoon, NL Jeon, YT Kim - Nano Convergence, 2021 - Springer
Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …

Modeling Crevicular Fluid Flow and Host‐Oral Microbiome Interactions in a Gingival Crevice‐on‐Chip

H Makkar, Y Zhou, KS Tan, CT Lim… - Advanced Healthcare …, 2023 - Wiley Online Library
Gingival crevice and gingival crevicular fluid (GCF) flow play a crucial role at the gingiva‐
oral microbiome interface which contributes toward maintaining the balance between …