The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Potassium channels play important roles in vital cellular signaling processes in both
excitable and nonexcitable cells. Over 50 human genes encoding various K+ channels have …

In the mammalian heart, Ca2+‐independent, depolarization‐activated potassium (K+)
currents contribute importantly to shaping the waveforms of action potentials, and several …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Ion channels, like many other proteins, have moving parts that perform useful functions. The
channel proteins contain an aqueous, ion-selective pore that crosses the plasma …

The congenital long-QT syndrome (LQTS) is characterized by prolonged QT intervals, QT
interval lability, and polymorphic ventricular tachycardia. The manifestations of the disease …

Recent advances in molecular biology have had a major impact on our understanding of the
biophysical and molecular properties of ion channels. This review is focused on cardiac …

HERG, the human ether-a-go-go–related gene, encodes a K+-selective channel with
properties similar to the rapidly activating component of the delayed rectifier K+ current (I Kr) …

Voltage-gated K+ channels are protein complexes composed of ion-conducting integral
membrane α subunits and cytoplasmic β subunits. Here, we show that, in transfected …

The differential expression and association of cytoplasmic β-subunits with pore-forming α-
subunits may contribute significantly to the complexity and heterogeneity of voltage-gated …