Long noncoding RNAs in cancer metastasis

SJ Liu, HX Dang, DA Lim, FY Feng… - Nature Reviews Cancer, 2021 - nature.com
Metastasis is a major contributor to cancer-associated deaths. It is characterized by a
multistep process that occurs through the acquisition of molecular and phenotypic changes …

TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis

Y Hao, D Baker, P Ten Dijke - International journal of molecular sciences, 2019 - mdpi.com
Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …

New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

ZT Yao, YM Yang, MM Sun, Y He, L Liao… - Cancer …, 2022 - Wiley Online Library
With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …

[HTML][HTML] Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

M Zhang, H Yang, L Wan, Z Wang, H Wang, C Ge… - Journal of …, 2020 - Elsevier
Background & Aims Intrahepatic cholangiocarcinoma (ICC) is the second most common liver
malignancy. ICC typically features remarkable cellular heterogeneity and a dense stromal …

Prognostic and therapeutic implications of microvascular invasion in hepatocellular carcinoma

DJ Erstad, KK Tanabe - Annals of surgical oncology, 2019 - Springer
Hepatocellular carcinoma (HCC) is a morbid condition for which surgical and ablative
therapy are the only options for cure. Nonetheless, over half of patients treated with an R0 …

The role of long noncoding RNAs in hepatocellular carcinoma

Z Huang, JK Zhou, Y Peng, W He, C Huang - Molecular cancer, 2020 - Springer
Hepatocellular carcinoma (HCC) is the most frequent subtype of primary liver cancer and
one of the leading causes of cancer-related death worldwide. However, the molecular …

A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis

Y Wang, L Yang, T Chen, X Liu, Y Guo, Q Zhu, X Tong… - Molecular cancer, 2019 - Springer
Background Hepatocellular carcinoma (HCC) is the most common malignant liver tumor with
poor clinical outcomes. Increasing amount of long non-coding RNAs (lncRNAs) have been …

LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway

N Wu, M Jiang, H Liu, Y Chu, D Wang, J Cao… - Cell Death & …, 2021 - nature.com
Abstrict LINC00941 is a novel lncRNA that has been found to exhibit protumorigenic and
prometastatic behaviors during tumorigenesis. However, its role in metastatic CRC remains …

Decoding hepatocarcinogenesis from a noncoding RNAs perspective

MKA El‐Aziz, A Dawoud, CJ Kiriacos… - Journal of cellular …, 2023 - Wiley Online Library
Being a leading lethal malignancy worldwide, the pathophysiology of hepatocellular
carcinoma (HCC) has gained a lot of interest. Yet, underlying mechanistic basis of the liver …

A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3

Y Zhou, Y Shao, W Hu, J Zhang, Y Shi… - Cell Death & …, 2023 - nature.com
Although radiotherapy is an essential modality in the treatment of colorectal cancer (CRC),
the incidence of radioresistance remains high clinically. Long noncoding RNAs (lncRNAs) …