Abstract Polo-like kinase 1 (PLK1) plays an important role in the initiation, maintenance, and
completion of mitosis. Dysfunction of PLK1 may promote cancerous transformation and drive …

Polo-like kinase 1 (PLK1) is a serine/threonine kinase with more than 600 phosphorylation
substrates through which it regulates many biological processes, including mitosis …

The deregulation of BCL2 family proteins plays a crucial role in leukemia development.
Therefore, pharmacological inhibition of this family of proteins is becoming a prevalent …

The PI3K/AKT signaling pathway plays a role in most cellular functions linked to cancer
progression, including cell growth, proliferation, cell survival, tissue invasion and …

The Bruton tyrosine kinase (BTK) inhibitor ibrutinib has substantially improved therapeutic
options for chronic lymphocytic leukemia (CLL). Although ibrutinib is not curative, it has a …

Nuclear factor (NF)-κB is a transcription factor that plays significant role in immunity, cellular
survival and inhibition of apoptosis, through the induction of genetic networks. Depending …

Objective A thorough examination of PLKs in breast cancer, including their expression and
prognosis. Methods With the help of the Oncomine database, the transcript levels of PLKs in …

Coactivator-associated arginine methyltransferase 1 (CARM1) is involved in a variety of
biological processes in different cell types and disease conditions, including myogenesis …

Natural killer/T cell lymphoma (NKTCL) is a highly aggressive subtype of non-Hodgkin
lymphoma. Gemcitabine, oxaliplatin, and L-asparaginase (GELOX) is one of the first-line …

C-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in
regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation …