Simple Summary DNA repair pathways play a crucial role in maintaining the stability of a
cell's genetic material. When these pathways are defective, it can lead to genomic instability …

Numerous eukaryotic DNA processing enzymes, such as DNA polymerases and ligases,
bind the processivity factor PCNA, which acts as a platform to recruit and regulate the …

During DNA replication, the proliferating cell nuclear antigen (PCNA) clamps are loaded
onto primed sites for each Okazaki fragment synthesis by the AAA+ heteropentamer …

The final steps of lagging strand synthesis induce maturation of Okazaki fragments via
removal of the RNA primers and ligation. Iterative cycles between Polymerase δ (Polδ) and …

Proliferating cell nuclear antigen (PCNA) is a homo-trimeric clamp complex that serves as
the molecular hub for various DNA transactions, including DNA synthesis and post …

Humans have three different proliferating cell nuclear antigen (PCNA) clamp-loading
complexes: RFC and CTF18-RFC load PCNA onto DNA, but ATAD5-RFC can only unload …

Nucleotide excision repair (NER) is the most universal repair pathway, which removes a
wide range of DNA helix-distorting lesions caused by chemical or physical agents. The final …

The coordination of enzymes and regulatory proteins for eukaryotic DNA replication and
repair is largely achieved by Proliferating Cell Nuclear Antigen (PCNA), a toroidal …

The human neuroblastoma cell lines SH-SY5Y and IMR-32 can be differentiated into neuron-
like phenotypes through treatment with all-trans-retinoic acid (ATRA). After differentiation …

The sliding clamp PCNA is a key player in eukaryotic genome replication and stability,
acting as a platform onto which components of the DNA replication and repair machinery are …