Rational target therapy of cancer would benefit from the identification of new targets that can
be easily inhibited by small molecules. An increasing amount of evidence hints at 3 …

The placenta is the main determinant of fetal growth and development in utero. It supplies all
the nutrients and oxygen required for fetal growth and secretes hormones that facilitate …

Elucidating the determinants of aggressiveness in lethal prostate cancer may stimulate
therapeutic strategies that improve clinical outcomes. We used experimental models and …

Hydrogen sulfide (H2S) is involved in cancer biological processes. However, there are
several controversies concerning the role of H2S in cancer development and progression. In …

The insulin-like growth factor (IGF) 2/IGF1 receptor (IGF1R) signaling axis has an important
role in intestinal carcinogenesis and overexpression of IGF2 is an accepted risk factor for …

Hepatocellular carcinoma (HCC) is the sixth most frequent human cancer and the world's
third most significant cause of cancer mortality. HCC treatment has recently improved, but its …

The molecular evolution processes underlying the acquisition of the placenta in eutherian
ancestors are not fully understood. Mouse NCK-interacting kinase (NIK)-related kinase …

Objective The recommended daily intakes of vitamin D according to the recent Clinical
Practice Guideline (CPG) of the Endocrine Society are three-to fivefold higher than the …

Tumor angiogenesis plays a critical role in hepatocellular carcinoma (HCC) development
and progression, but its mechanism is unclear. Krüppel-like factor 8 (KLF8) is a transcription …

Imprinting control region (ICR1) controls the expression of the Igf2 and H19 genes in a
parent-of-origin specific manner. Appropriate expression of the Igf2-H19 locus is …