Overall survival rates for pediatric patients with high‐risk or relapsed rhabdomyosarcoma
(RMS) have not improved significantly since the 1980s. Recent studies have identified a …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood, with
presumed skeletal muscle origins, because of its myogenic phenotype. RMS is composed of …

Fate-changing transcription factors (TFs) scan chromatin to initiate new genetic programs
during cell differentiation and reprogramming. Yet the protein structure domains that allow …

Myoblast fusion is essential for formations of myofibers, the basic cellular and functional
units of skeletal muscles. Recent genetic studies in mice identified two long-sought …

The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here
we report that YAP1 activity is elevated in human embryonal rhabdomyosarcoma (ERMS). In …

Rhabdomyosarcoma (RMS) is an aggressive pediatric malignancy of the muscle, that
includes Fusion Positive (FP)-RMS harboring PAX3/7-FOXO1 and Fusion Negative (FN) …

Rhabdomyosarcoma (RMS) is the most common soft‐tissue sarcoma in children and
adolescents, being characterized by expression of genes and morphological and …

Rhabdomyosarcoma, a neoplasm composed of skeletal myoblast-like cells, represents the
most common soft tissue sarcoma in children. The application of intensive …

Elevated levels of PAX3 and cell proliferation genes are characteristic features of
rhabdomyosarcoma (RMS). We hypothesize that the increased levels of these genes are …

Myogenesis is a complex process required for skeletal muscle formation during embryonic
development and for regeneration and growth of myofibers in adults. Accumulating evidence …