Little is known concerning the precise molecular pathway that links fluid-phase molecules to
those in nascent crystal nuclei. In this paper the process of molecular self-assembly has …

The measurement of solubility in microsamples employing a differential scanning
calorimeter (DSC) has been evaluated for several aqueous and nonaqueous systems …

Pure enantiomers are of large interest for several industries. Chemical synthesis is
frequently not selective and provides racemic mixtures causing a large interest in efficient …

Mandelic acids are prototypic chiral molecules where the sensitivity of crystallized forms
(enantiopure/racemic compound/polymorphs) to both conditions and substituents provides a …

This article describes the synthesis and characterization of new cocrystals of ciprofloxacin
with nicotinic and isonicotinic acids as coformers. The cocrystals were obtained by a …

A systematic study of the binary melting point phase diagram and ternary solubility phase
diagram of the enantiomeric mandelic acid species in water has been undertaken. The …

The purpose of this work is to increase the efficiency of the cocrystal formation process by
thermodynamic modeling using perturbed-chain statistical associating fluid theory (PC …

Chiral molecules are challenging for the pharmaceutical industry because although physical
properties of the enantiomers are the same in achiral systems, they exhibit different effects in …

In this work, the solubilities of (R)-and (R, S)-crizotinib in six solvents including methanol,
ethanol, 1-propanol, 1-butanol, ethyl acetate, and n-hexane were first measured by a static …

Pharmaceutical Isothermal Calorimetry discusses the application of isothermal calorimetric
techniques to challenges encountered during the rational design and development of novel …