Neonatal diabetes mellitus (NDM) is noted as a genetic, heterogeneous, and rare disease in
infants. NDM occurs due to a single-gene mutation in neonates. A common source for …

A comprehensive understanding of mechanisms that underlie the development and function
of human cells requires human cell models. For the pancreatic lineage, protocols have been …

Finding new causes of monogenic diabetes helps understand glycaemic regulation in
humans. To find novel genetic causes of maturity-onset diabetes of the young (MODY), we …

Abstract Objective Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut
luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy …

We report a recurrent CNOT1 de novo missense mutation, GenBank: NM_016284. 4; c.
1603C> T (p. Arg535Cys), resulting in a syndrome of pancreatic agenesis and abnormal …

Transcriptional factor RFX6 is known to be a causal gene of Mitchell–Riley syndrome (MRS),
an autosomal recessive neonatal diabetes associated with pancreatic hypoplasia and …

The occurrence of diabetes mellitus is characterized by pancreatic β cell loss and chronic
hyperglycemia. While Type 1 and Type 2 diabetes are the most common types, rarer forms …

To summarize the clinical characteristics, diagnosis, treatment and prognosis among 152
children with annular pancreas (AP). A retrospective review of 152 patients with AP who …

Background Homozygous mutations in the transcription factor RFX6 are the cause of the
Mitchell–Riley syndrome (MRS) associating neonatal diabetes, congenital digestive system …

Introduction: Monogenic diabetes (MD) accounts for 3%–6% of all cases of diabetes. This
prevalence is underestimated due to its overlapping clinical features with type 1 and type 2 …