[HTML][HTML] Solid-state NMR spectroscopy in pharmaceutical sciences

M Li, W Xu, Y Su - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …

The use of amorphous solid dispersions: A formulation strategy to overcome poor solubility and dissolution rate

G Van den Mooter - Drug Discovery Today: Technologies, 2012 - Elsevier
The use of amorphous solid dispersions is an interesting strategy to increase the
bioavailability of poorly soluble drugs by improving their rate and extent of dissolution. Lack …

Evaluation of amorphous solid dispersion properties using thermal analysis techniques

JA Baird, LS Taylor - Advanced drug delivery reviews, 2012 - Elsevier
Amorphous solid dispersions are an increasingly important formulation approach to improve
the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their …

Assessing the performance of amorphous solid dispersions

A Newman, G Knipp, G Zografi - Journal of pharmaceutical sciences, 2012 - Elsevier
The characterization and performance of stable amorphous solid dispersion systems were
evaluated in 40 research papers reporting active pharmaceutical ingredient (API) dissolution …

Applications of high-resolution 1H solid-state NMR

SP Brown - Solid State Nuclear Magnetic Resonance, 2012 - Elsevier
This article reviews the large increase in applications of high-resolution 1H magic-angle
spinning (MAS) solid-state NMR, in particular two-dimensional heteronuclear and …

Investigating miscibility and molecular mobility of nifedipine-PVP amorphous solid dispersions using solid-state NMR spectroscopy

X Yuan, D Sperger, EJ Munson - Molecular pharmaceutics, 2014 - ACS Publications
Solid-state NMR (SSNMR) 1H T1 and T1ρ relaxation times were used to evaluate the
miscibility of amorphous solid dispersions of nifedipine (NIF) and polyvinylpyrrolidone (PVP) …

Selective laser sintering 3-dimensional printing as a single step process to prepare amorphous solid dispersion dosage forms for improved solubility and dissolution …

DA Davis Jr, R Thakkar, Y Su, RO Williams III… - Journal of …, 2021 - Elsevier
This study reports the development of ritonavir-copovidone amorphous solid dispersions
(ASDs) and dosage forms thereof using selective laser sintering (SLS) 3-dimensional (3-D) …

Investigation of drug–excipient interactions in lapatinib amorphous solid dispersions using solid-state NMR spectroscopy

Y Song, X Yang, X Chen, H Nie, S Byrn… - Molecular …, 2015 - ACS Publications
This study investigated the presence of specific drug–excipient interactions in amorphous
solid dispersions of lapatinib (LB) and four commonly used pharmaceutical polymers …

Dynamic nuclear polarization enhanced NMR spectroscopy for pharmaceutical formulations

AJ Rossini, CM Widdifield, A Zagdoun… - Journal of the …, 2014 - ACS Publications
Dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy at 9.4 T is
demonstrated for the detailed atomic-level characterization of commercial pharmaceutical …

Physical stability of pharmaceutical formulations: solid-state characterization of amorphous dispersions

Y Guo, E Shalaev, S Smith - TrAC Trends in Analytical Chemistry, 2013 - Elsevier
The acceptable stability of the drug formulations is one of the basic requirements for
pharmaceutical development and commercialization. The increasing application of enabling …