Abstract Purpose of Review Multicentric carpotarsal osteolysis (MCTO) is an ultra-rare
disorder characterized by osteolysis of the carpal and tarsal bones, subtle craniofacial …

Large musculoaponeurotic fibrosarcoma (MAF) transcription factors contain acidic, basic,
and leucine zipper regions. Four types of MAF have been elucidated in mice and humans …

Macrophage phenotypic and functional heterogeneity derives from tissue-specific
transcriptional signatures shaped by the local microenvironment. Most studies addressing …

Here we report the use of denosumab, a monoclonal antibody against receptor activator of
nuclear factor κB ligand (RANKL), as monotherapy for multicentric carpotarsal osteolysis …

The MafB transcription factor is expressed in pancreatic α and β cells during development
but becomes exclusive to α cells in adult rodents. Mafb-null (Mafb−/−) mice were reported to …

Monocyte-derived macrophages, the major source of pathogenic macrophages in COVID-
19, are oppositely instructed by macrophage CSF (M-CSF) or granulocyte macrophage CSF …

Multicentric carpo-tarsal osteolysis (MCTO) is a rare osteolysis syndrome mainly involving
carpal and tarsal bones usually presenting in early childhood. MCTO has autosomal …

Multicentric carpotarsal osteolysis syndrome (MCTO), an autosomal dominant disorder that
often presents sporadically, features carpal–tarsal lysis frequently followed by nephropathy …

MCTO is a rare disorder, caused by mutations in the MafB gene, a negative regulator of
receptor activator of nuclear factor-кB ligand (RANKL). Manifestations include carpal and …

Multicentric carpo-tarsal osteolysis syndrome (MCTO) is a rare skeletal disorder commonly
caused by MAF bZIP transcription factor B (MAFB) mutation. Clinically, it is characterized by …