The differentiation of T helper cell subsets and their acquisition of effector functions are
accompanied by changes in gene expression programmes, which in part are regulated and …

Recent evidence suggests that autophagy facilitates the unconventional secretion of the pro-
inflammatory cytokine interleukin 1β (IL-1β). Here, we reconstituted an autophagy-regulated …

Successful immunity depends upon the activity of multiple cell types. Commitment of
pluripotent precursor cells to specific lineages, such as T or B cells, is obviously fundamental …

Molecular mechanisms that maintain lineage integrity of helper T cells are largely unknown.
Here we show histone deacetylases 1 and 2 (HDAC1 and HDAC2) as crucial regulators of …

Some effector CD4+ T cell subsets display cytotoxic activity, thus breaking the functional
dichotomy of CD4+ helper and CD8+ cytotoxic T lymphocytes. However, molecular …

Objective Genome-wide association studies (GWAS) have identified multiple risk loci for
Crohn's disease (CD). However, the cumulative risk exerted by these loci is low, and the …

The helper versus cytotoxic-lineage choice of CD4+ CD8+ DP thymocytes correlates with
MHC restriction of their T cell receptors and the termination of either CD8 or CD4 coreceptor …

Intrathymic CD4/CD8 differentiation is a process that establishes the mutually exclusive
expression profiles of the CD4 and CD8 T cell lineage. The RUNX3-mediated silencing of …

Hepatocarcinogenesis is a multi-step process. However, the regulators of hepatocellular
carcinoma (HCC) initiation are understudied. Adult liver-specific gene expression was …

The Th-inducing POK (Th-POK, also known as ZBTB7B or cKrox) transcription factor is a key
regulator of lineage commitment of immature T cell precursors. It is yet unclear the …