Conformational changes in the Niemann–Pick type C1 protein NCR1 drive sterol translocation
The membrane protein Niemann–Pick type C1 (NPC1, named NCR1 in yeast) is central to
sterol homeostasis in eukaryotes. Saccharomyces cerevisiae NCR1 is localized to the …
sterol homeostasis in eukaryotes. Saccharomyces cerevisiae NCR1 is localized to the …
[HTML][HTML] First data on cholesterol metabolism in Ornithodoros argasid ticks: Molecular and functional characterization of the N-terminal domain of Niemann-Pick C1 …
L de Dios-Blázquez, AL Cano-Argüelles… - Ticks and tick-borne …, 2024 - Elsevier
Cholesterol is a molecule vital for tick physiology, but ticks cannot synthesize it and rely on
dietary cholesterol. Therefore, tick proteins involved in cholesterol absorption and transport …
dietary cholesterol. Therefore, tick proteins involved in cholesterol absorption and transport …
NPC Intracellular Cholesterol Transporter 1 Regulates Ovarian Maturation and Molting in Female Macrobrachium nipponense
S Jiang, W Zhang, Y Xiong, M Zhang, H Yuan… - International Journal of …, 2024 - mdpi.com
NPC intracellular cholesterol transporter 1 (NPC1) plays an important role in sterol
metabolism and transport processes and has been studied in many vertebrates and some …
metabolism and transport processes and has been studied in many vertebrates and some …
[HTML][HTML] The point mutation of the cholesterol trafficking membrane protein NPC1 may affect its proper function in more than a single step: molecular dynamics …
Abstract The Niemann-Pick type C1 (NPC1) protein is one of the key players of cholesterol
trafficking from the lysosome and its function is closely coupled with the Niemann-Pick type …
trafficking from the lysosome and its function is closely coupled with the Niemann-Pick type …
Functional analysis of a NPC1 gene from the whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae)
H Yu, L Wang, S Liu, X Chen, X Wei… - Archives of Insect …, 2023 - Wiley Online Library
Abstract Niemann‐Pick C (NPC) disease is a neurodegenerative disorder related to cellular
sterol trafficking and mutation of NPC1 gene is the main cause for this disease. The function …
sterol trafficking and mutation of NPC1 gene is the main cause for this disease. The function …
Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related protein
L Nel, K Thaysen, D Jamecna, E Olesen… - Life Science …, 2025 - life-science-alliance.org
In eukaryotes, integration of sterols into the vacuolar/lysosomal membrane is critically
dependent on the Niemann–Pick type C (NPC) system. The system consists of an integral …
dependent on the Niemann–Pick type C (NPC) system. The system consists of an integral …
Heterologous expression of MiMLDP, a major lipid droplet protein of the microalga Myrmecia incisa, in Saccharomyces cerevisiae promotes more triacylglycerol …
JM Hu, Z Sun, QH Xu, XP Fang, YH Bi, ZG Zhou - Algal Research, 2023 - Elsevier
In some algae, lipid droplets (LDs) are surrounded by phospholipid monolayers containing
specialized proteins such as major lipid droplet protein (MLDP), which serves as a principal …
specialized proteins such as major lipid droplet protein (MLDP), which serves as a principal …
Estudio farmacogenético en Saccharomyces cerevisae: identificación de genes moduladores de la respuesta a Rapamicina en la enfermedad de Niemann Pick tipo …
PB Szenfeld Espinosa - 2023 - repositorio.uchile.cl
La enfermedad de Niemann Pick tipo C (NPC) es un trastorno de almacenamiento
lisosomal causado por mutaciones de pérdida de función en los genes NPC1 y NPC2, que …
lisosomal causado por mutaciones de pérdida de función en los genes NPC1 y NPC2, que …