Dimethoxyindoles based thiosemicarbazones as multi-target agents; synthesis, crystal interactions, biological activity and molecular modeling

M Yıldız, M Bingul, Y Zorlu, MF Saglam, M Boga… - Bioorganic …, 2022 - Elsevier
Alzheimer's disease (AD) is known as one of the most devastating neurodegenerative
disease diagnosed for the old-aged people and cholinesterase inhibitors (ChEI) can be …

Comparison of singlet oxygen production of ethyl vanillin substituted silicon phthalocyanine using sonophotodynamic and photodynamic methods

CC Karanlık, GY Atmaca, A Erdoğmuş - Journal of Molecular Structure, 2023 - Elsevier
Abstract Although Sonophotodynamic Therapy (SPDT) studies, which are a new approach
that give better results than Photodynamic Therapy (PDT) in which light and sound are used …

Water-soluble phthalocyanine photosensitizers for photodynamic therapy

İ Ömeroğlu, M Durmuş - Turkish Journal of Chemistry, 2023 - journals.tubitak.gov.tr
Photodynamic therapy (PDT) is based on a photochemical reaction that is started when a
photosensitizing process is activated by the light and results in the death of tumor cells …

Synthesis and molecular modeling studies of naphthazarin derivatives as novel selective inhibitors of α-glucosidase and α-amylase

Ş Abadan, MF Saglam, MS Koca, M Bingul… - Journal of Molecular …, 2023 - Elsevier
Diabetes mellitus is known as one of the most life-threatening diseases and has attracted
the attention of medicinal chemists. The design and synthesis of novel potential candidates …

Synthesis of 7-azaindole based carbohydrazides and 1, 3, 4-oxadiazoles; antioxidant activity, α-glucosidase inhibition properties and docking study

S Izgi, IF Sengul, E Şahin, MS Koca, F Cebeci… - Journal of Molecular …, 2022 - Elsevier
In this current work, 7-azaindole based 1, 3, 4-oxadiazoles have been successfully prepared
by treatment of 3-(hydrazonomethyl)-7-azaindole with the different acyl chlorides or acetic …

Assessment of in vitro Cytotoxic, iNOS, Antioxidant and Photodynamic Antimicrobial Activities of Water‐soluble Sulfonated Phthalocyanines

M Akin, N Saki, E Guzel, B Orman… - Photochemistry and …, 2022 - Wiley Online Library
In recent years, much effort has been devoted to the development of effective anticancer
agents. In this manner, the utilization of water‐soluble sulfonated phthalocyanines is crucial …

The phenoxy-bearing naphthalimide substituted phthalocyanines: Photophysicochemical and biological properties

T Küçük, K Harmandar, MS Yalçın, ŞŞ Ün… - Polyhedron, 2024 - Elsevier
Abstract New Si (IV) phthalocyanine (Pc)(1) derivative including axially phenoxy bearing
naphthalimide and peripheraly t-butyl groups was synthesized and photophysicochemical …

Photodynamic therapy using silicon phthalocyanine conjugated with bovine serum albumin as a drug delivery system

EPO Silva, NM Ribeiro, MAG Cardoso… - Laser …, 2021 - iopscience.iop.org
In the present study, we describe a new silicon phthalocyanine conjugated to bovine serum
albumin (PcSiN3M-BSA) and its photodynamic activity in murine macrophages cells (J774 …