Oxidative stress in vascular calcification

CT Hu, YD Shao, YZ Liu, X Xiao, ZB Cheng, SL Qu… - Clinica chimica acta, 2021 - Elsevier
Vascular calcification (VC), which is closely associated with significant mortality in
cardiovascular disease, chronic kidney disease (CKD), and/or diabetes mellitus, is …

Vascular calcification and cellular signaling pathways as potential therapeutic targets

JH Kang, T Kawano, M Murata, R Toita - Life Sciences, 2023 - Elsevier
Increased vascular calcification (VC) is observed in patients with cardiovascular diseases
such as atherosclerosis, diabetes, and chronic kidney disease. VC is divided into three types …

[HTML][HTML] Unraveling the role of carboxylate groups and elastin particle size in medial calcification

T Song, M Cerruti - International Journal of Biological Macromolecules, 2024 - Elsevier
While it is known that calcium phosphate (CaP) minerals deposit in elastin-rich medial layers
of arteries during medial calcification, their nucleation and growth sites are still debated …

Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease

FG Rodrigues, MS Ormanji, IP Heilberg… - European Journal of …, 2021 - Wiley Online Library
Deregulations in gut microbiota may play a role in vascular and bone disease in chronic
kidney disease (CKD). As glomerular filtration rate declines, the colon becomes more …

Scavenging Intracellular ROS Attenuates p-Cresyl Sulfate-Triggered Osteogenesis through MAPK Signaling Pathway and NF-κB Activation in Human Arterial Smooth …

JF Chang, CY Hsieh, JC Liou, SH Liu, CF Hung, KC Lu… - Toxins, 2020 - mdpi.com
Osteogenesis in human arterial smooth muscle cell (HASMC) is a key feature of uremic
vascular calcification (UVC). Concerning pro-oxidant properties of p-cresyl sulfate (PCS), the …

The impact of fetuin-A on predicting aortic arch calcification: secondary analysis of a community-based survey

YH Lin, MH Lin, CS Shi, YS Lin, CL Lin… - Frontiers in …, 2024 - frontiersin.org
Introduction Atherosclerotic cardiovascular disease is associated with a high mortality rate
due to vascular calcification. The role of fetuin-A in aortic arch calcification (AAC) is less well …

Translational medicine in uremic vascular calcification: scavenging ROS attenuates p-cresyl sulfate-activated caspase-1, NLRP3 inflammasome and eicosanoid …

JF Chang, HL Kuo, SH Liu, CY Hsieh, CP Hsu… - Life, 2022 - mdpi.com
We formerly proved that uremic vascular calcification (UVC) correlates tightly with oxidative
elastic lamina (EL) injury and two cell fates (apoptosis and osteocytic conversion) in smooth …

Trajectory of estimated glomerular filtration rate and malnourishment predict mortality and kidney failure in older adults with chronic kidney disease

SC Weng, CM Chen, YC Chen, MJ Wu… - Frontiers in …, 2021 - frontiersin.org
Objective: The trajectory patterns of estimated glomerular filtration rates (eGFR) in chronic
kidney disease (CKD) older adults with malnourishment and their association with …

Circulating p-Cresyl Sulfate, Non-Hepatic Alkaline Phosphatase and Risk of Bone Fracture Events in Chronic Kidney Disease-Mineral Bone Disease

JF Chang, CY Hsieh, JC Liou, KC Lu, CM Zheng… - Toxins, 2021 - mdpi.com
Patients with chronic kidney disease (CKD), especially those undergoing hemodialysis, are
at a considerably high risk of bone fracture events. Experimental data indicate that uremic …

[HTML][HTML] Role of Mitochondrial Dysfunction in CKD-related Vascular Calcification: From Mechanisms to Therapeutics

J Huang, J Hao, P Wang, Y Xu - Kidney International Reports, 2024 - Elsevier
Vascular calcification (VC) is a common complication of chronic kidney disease (CKD) and
is closely associated with cardiovascular events. The transdifferentiation of vascular smooth …