Osteoporosis is a bone disorder with remarkable changes in bone biologic material and
consequent bone structural distraction, affecting millions of people around the world from …

Postmenopausal osteoporosis is the most common bone disease, associated with low bone
mineral density (BMD) and pathological fractures which lead to significant morbidity. It is …

Introduction Long-term treatment is used in patients with osteoporosis, and bisphosphonates
(BPs) are the most commonly prescribed medications. However, in some patients this …

Bisphosphonates (BPs) are potent inhibitors of osteoclastmediated bone resorption. They
are widely used in the management of osteoporosis and other diseases of high bone …

Osteonecrosis of the jaw (ONJ) is a rare but serious drug induced adverse event, mainly
associated with the use of antiresorptive medications, such as intravenous (IV) …

An undesirable effect associated with bisphosphonates is osteonecrosis of the jaw (ONJ).
Case reports discussed ONJ development in patients with multiple myeloma or metastatic …

Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication that can
develop in patients treated with anti-resorptive drugs. Although the pathogenesis of MRONJ …

Zoledronic acid is a bisphosphonate commonly used to treat bone diseases such as
osteoporosis and cancer induced bone disease. Patients exhibit a variable sensitivity to …

Farnesyl diphosphate synthase (FDPS) is necessary for osteoclast survival and activity and
is considered as a major molecular target of aminobisphosphonates. Our objective was to …

Introduction: Osteoporosis is a highly prevalent skeletal disorder characterized by
compromised bone strength, usually related to decreased bone mass and microstructural …