Small‐Molecule Quenchers for Förster Resonance Energy Transfer: Structure, Mechanism, and Applications

B Fang, Y Shen, B Peng, H Bai, L Wang… - Angewandte …, 2022 - Wiley Online Library
For fluorogenic probes, Förster resonance energy transfer (FRET) is one of the most widely
used mechanisms to realize the detection of biochemical activities. Dark quenchers relax …

Recent advances in DNA-based probes for Photoacoustic Imaging

A Anil, J Chaskar, AB Pawar, A Tiwari… - Journal of Biotechnology, 2024 - Elsevier
Photoacoustic imaging (PAI) is a widely developing imaging modality that has seen
tremendous evolvement in the last decade. PAI has gained the upper hand in the imaging …

Supramolecular Loading of DNA Hydrogels with Dye–Drug Conjugates for Real‐Time Photoacoustic Monitoring of Chemotherapy

RM Borum, C Moore, Y Mantri, M Xu… - Advanced …, 2023 - Wiley Online Library
A longstanding problem with conventional cancer therapy is the nonspecific distribution of
chemotherapeutics. Monitoring drug release in vivo via noninvasive bioimaging can thus …

pH-activatable cyanine dyes for selective tumor imaging using near-infrared fluorescence and photoacoustic modalities

H Mu, K Miki, H Harada, K Tanaka, K Nogita… - ACS sensors, 2020 - ACS Publications
Photoacoustic (PA) imaging is an emerging molecular imaging modality that complements
fluorescence imaging and enables high resolution within deep tissue. Fluorescence/PA …

An activatable cancer-targeted hydrogen peroxide probe for photoacoustic and fluorescence imaging

J Weber, L Bollepalli, AM Belenguer, MD Antonio… - Cancer research, 2019 - AACR
Reactive oxygen species play an important role in cancer, however, their promiscuous
reactivity, low abundance, and short-lived nature limit our ability to study them in real time in …

[HTML][HTML] Multiplexed non-invasive tumor imaging of glucose metabolism and receptor-ligand engagement using dark quencher FRET acceptor

A Rudkouskaya, N Sinsuebphon, M Ochoa, SJ Chen… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Following an ever-increased focus on personalized medicine, there is a
continuing need to develop preclinical molecular imaging modalities to guide the …

An Indocyanine Green‐Based Nanoprobe for In Vivo Detection of Cellular Senescence

AG Baker, M Hartono, HL Ou, AB Popov… - Angewandte Chemie …, 2024 - Wiley Online Library
There is an urgent need to improve conventional cancer‐treatments by preventing
detrimental side effects, cancer recurrence and metastases. Recent studies have shown that …

A photoacoustic contrast agent for miR-21 via NIR fluorescent hybridization chain reaction

RM Borum, C Moore, SK Chan… - Bioconjugate …, 2021 - ACS Publications
Nucleic acids are well-established biomarkers of cancer with immense value in diagnostics
and basic research. However, strategies to monitor these species in tissue can be …

Photoacoustic polydopamine-indocyanine green (PDA-ICG) nanoprobe for detection of senescent cells

M Hartono, AG Baker, TR Else, AS Evtushenko… - Scientific Reports, 2024 - nature.com
Cellular senescence is considered an important tumour suppression mechanism in
response to damage and oncogenic stress in early lesions. However, when senescent cells …

DNA‐Based Nanocarriers to Enhance the Optoacoustic Contrast of Tumors In Vivo

J Joseph, KN Baumann, A Postigo… - Advanced …, 2021 - Wiley Online Library
Optoacoustic tomography (OT) enables non‐invasive deep tissue imaging of optical contrast
at high spatio‐temporal resolution. The applications of OT in cancer imaging often rely on …