Noncovalent, extrinsic fluorescent dyes are applied in various fields of protein analysis, eg to
characterize folding intermediates, measure surface hydrophobicity, and detect aggregation …

The development towards a sustainable society requires a radical change of many of the
materials we currently use. Besides the replacement of plastics, derived from petrochemical …

Amyloid fibrillation of food-derived dietary proteins has been increasingly accepted as an
effective approach to enhance protein functionality. Soy protein, an abundant and …

Amyloid fiber formation is a key event in many misfolding disorders. The ability to monitor the
kinetics of fiber formation and other prefibrillar assemblies is therefore crucial for …

The presence of particles is a major issue during therapeutic protein formulation
development. Both proteinaceous and nonproteinaceous particles need to be analyzed not …

Proteins are essential elements for life. They are building blocks of all organisms and the
operators of cellular functions. Humans produce a repertoire of at least 30,000 different …

Aggregation of a biotherapeutic is of significant concern and judicious process and
formulation development is required to minimize aggregate levels in the final product …

The fibrillar aggregation at pH 2.0 of soy β-conglycinin, glycinin, and the 1: 1 mixture thereof,
induced by heating at 80° C for various periods of time, was investigated using Th T and …

Protein aggregation is a widespread phenomenon that stems from the establishment of non-
native intermolecular contacts resulting in protein precipitation. Despite its deleterious …

At low pH insulin is highly prone to self-assembly into amyloid fibrils. The process has been
proposed to be affected by the existence of secondary nucleation pathways, in which …