Kidney organoids are regarded as important tools with which to study the development of
the normal and diseased human kidney. Since the first reports of human pluripotent stem …

There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …

Background Single-cell RNA sequencing has been widely adopted to estimate the cellular
composition of heterogeneous tissues and obtain transcriptional profiles of individual cells …

Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …

Chronic kidney disease affects 10% of the population with notable differences in ethnic and
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …

Erythropoietin (Epo) is the master regulator of erythropoiesis and oxygen homeostasis.
Despite its physiological importance, the molecular and genomic contexts of the cells …

Single-cell sequencing studies have characterized the transcriptomic signature of cell types
within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional …

Background Current management of AKI, a potentially fatal disorder that can also initiate or
exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular …

Sexually dimorphic traits are common among mammals and are specified during
development through the deployment of sex-specific genetic programs. Because little is …

The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …