Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Cells ingest large particles, such as bacteria, viruses, or apoptotic cells, via the process of
phagocytosis, which involves formation of an actin-rich structure known as the phagocytic …

Immune cells have intensely physical lifestyles characterized by structural plasticity and
force exertion. To investigate whether specific immune functions require stereotyped …

Gaucher disease (GD) is the most common lysosomal storage disease caused by recessive
mutations in the degrading enzyme of β-glucosylceramide (β-GlcCer). However, it remains …

Phagocytosis is the process of engulfment and internalization of comparatively large
particles by cells, and plays a central role in the functioning of our immune system. We study …

Corals form an endosymbiotic relationship with the dinoflagellate algae Symbiodiniaceae,
but ocean warming can trigger algal loss, coral bleaching and death, and the degradation of …

Phagocytosis is an intensely physical process that depends on the mechanical properties of
both the phagocytic cell and its chosen target. Here, we employed differentially deformable …

Over a decade ago, it was discovered that microglia, the brain's immune cells, engulf
synaptic material in a process named microglial pruning. This term suggests that microglia …

Podosomes are actin-enriched adhesion structures important for multiple cellular processes,
including migration, bone remodeling, and phagocytosis. Here, we characterize the structure …

One ubiquitous cellular structure for performing various tasks, such as spreading and
migration over external surfaces, is the sheet-like protrusion called a lamellipodium, which …