The glomerulus is a highly specialized microvascular bed that filters blood to form primary
urinary filtrate. It contains four cell types: fenestrated endothelial cells, specialized vascular …

Much like cancer cells, activated T cells undergo various metabolic changes that allow them
to grow and proliferate rapidly. By adopting aerobic glycolysis upon activation, T cells …

Acute kidney injury (AKI) and chronic kidney disease (CKD) represent an important
challenge for healthcare providers. The identification of new biomarkers/pharmacological …

HIVAN results from direct infection by HIV-1 and expression of viral genes, especially Nef
and Vpr, in renal epithelial cells in a genetically susceptible host. The infected renal …

Viruses are capable of inducing a wide spectrum of glomerular disorders that can be
categorized on the basis of the duration of active viremia: acute, subacute, or chronic. The …

Patients undergoing long-term highly active antiretroviral therapy treatment are probably at a
higher risk of various HIV-related complications. Hyperactivation of The mammalian target of …

Autophagy is a highly conserved intracellular catabolic process for the degradation of
cytoplasmic components that has recently gained increasing attention for its importance in …

Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular
proliferation and survival which controls cellular response to different stresses, including …

The oral, cervical, and genital mucosa, covered by stratified squamous epithelia with
polarized organization and strong tight and adherens junctions, play a critical role in …

Recent evidence suggesting a potential anti‐CMV effect of mTORis is of great interest to the
transplant community. However, the concept of an immunosuppressant with antiviral …