Recent breakthroughs and future directions in drugging aquaporins
Aquaporins facilitate the passive transport of water, solutes, or ions across biological
membranes. They are implicated in diverse pathologies including brain edema following …
membranes. They are implicated in diverse pathologies including brain edema following …
The transporter-mediated cellular uptake and efflux of pharmaceutical drugs and biotechnology products: how and why phospholipid bilayer transport is negligible in …
DB Kell - Molecules, 2021 - mdpi.com
Over the years, my colleagues and I have come to realise that the likelihood of
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …
Cryo-EM structure supports a role of AQP7 as a junction protein
P Huang, R Venskutonytė, RB Prasad… - Nature …, 2023 - nature.com
Abstract Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane
with a critical physiological role linked to metabolism, obesity, and associated diseases …
with a critical physiological role linked to metabolism, obesity, and associated diseases …
[HTML][HTML] Structural basis for silicic acid uptake by higher plants
Many of the world's most important food crops such as rice, barley and maize accumulate
silicon (Si) to high levels, resulting in better plant growth and crop yields. The first step in Si …
silicon (Si) to high levels, resulting in better plant growth and crop yields. The first step in Si …
Aquaporin-7: a dynamic aquaglyceroporin with greater water and glycerol permeability than its bacterial homolog GlpF
FJ Moss, P Mahinthichaichan, DT Lodowski… - Frontiers in …, 2020 - frontiersin.org
Xenopus oocytes expressing human aquaporin-7 (AQP7) exhibit greater osmotic water
permeability and 3H-glycerol uptake vs. those expressing the bacterial glycerol facilitator …
permeability and 3H-glycerol uptake vs. those expressing the bacterial glycerol facilitator …
Aquaglyceroporin modulators as emergent pharmacological molecules for human diseases
Aquaglyceroporins, a sub-class of aquaporins that facilitate the diffusion of water, glycerol
and other small uncharged solutes across cell membranes, have been recognized for their …
and other small uncharged solutes across cell membranes, have been recognized for their …
The hidden intricacies of aquaporins: remarkable details in a common structural scaffold
Evolution turned aquaporins (AQPs) into the most efficient facilitators of passive water flow
through cell membranes at no expense of solute discrimination. In spite of a plethora of …
through cell membranes at no expense of solute discrimination. In spite of a plethora of …
Natural phenylethanoid glycosides diuretics derived from Lagopsis supina: biological activity, mechanism, molecular docking, and structure-activity relationship
L Yang, H Zeng, X Xia, H Wang, B Zhao, J He - Bioorganic Chemistry, 2022 - Elsevier
Aquaporins (AQPs) and vasopressin type 2 receptor (V2R) play a crucial role in urine
excretion and are widely used to explore novel diuretics. In this study, three …
excretion and are widely used to explore novel diuretics. In this study, three …
[HTML][HTML] The Important Role of Aquaglyceroporin 7 in Health and Disease
J Liu, Z Xia, S Peng, J Xia, R Xu, X Wang, F Li, W Zhu - Biomolecules, 2024 - mdpi.com
Aquaporins (AQPs) are highly conserved small transmembrane proteins that facilitate the
transport of water and small solutes across cell membranes. Aquaglyceroporin 7 (AQP7), a …
transport of water and small solutes across cell membranes. Aquaglyceroporin 7 (AQP7), a …
[HTML][HTML] Aquaporins–Expression, purification and characterization
Aquaporin water channels facilitate the bi-directional flow of water and small, neutral solutes
down an osmotic gradient in all kingdoms of life. Over the last two decades, the availability of …
down an osmotic gradient in all kingdoms of life. Over the last two decades, the availability of …