Peripheral voltage-gated cation channels in neuropathic pain and their potential as therapeutic targets
SRA Alles, PA Smith - Frontiers in Pain Research, 2021 - frontiersin.org
The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …
neurons is imperative for the development and persistence of many forms of neuropathic …
Fifteen years of NaV1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?
In 2006, humans with a congenital insensitivity to pain (CIP) were found to lack functional
NaV1. 7 channels. In the subsequent 15 years there was a rush to develop selective …
NaV1. 7 channels. In the subsequent 15 years there was a rush to develop selective …
A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome
Chronic pain is a serious debilitating condition that affects; 20% of the world's population.
Currently available drugs fail to produce effective pain relief in many patients and have dose …
Currently available drugs fail to produce effective pain relief in many patients and have dose …
Why to study peptides from venomous and poisonous animals?
AN de Oliveira, AM Soares, SL Da Silva - International Journal of Peptide …, 2023 - Springer
Venom and poison peptides are powerful biological weapons and have proven immense
pharmacological potential because of their high binding affinity to a wide range of molecular …
pharmacological potential because of their high binding affinity to a wide range of molecular …
Structure–Function and therapeutic potential of spider venom-derived cysteine knot peptides targeting sodium channels
FC Cardoso, RJ Lewis - Frontiers in pharmacology, 2019 - frontiersin.org
Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that
exhibit unique pharmacological properties to modulate key membrane protein targets …
exhibit unique pharmacological properties to modulate key membrane protein targets …
Holistic profiling of the venom from the Brazilian wandering spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics
Introduction: Spider venoms are a unique source of bioactive peptides, many of which
display remarkable biological stability and neuroactivity. Phoneutria nigriventer, often …
display remarkable biological stability and neuroactivity. Phoneutria nigriventer, often …
[HTML][HTML] PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold
Sea anemone venoms have long been recognized as a rich source of peptides with
interesting pharmacological and structural properties, but they still contain many …
interesting pharmacological and structural properties, but they still contain many …
Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V
BD Moyer, JK Murray, J Ligutti, K Andrews, P Favreau… - PLoS …, 2018 - journals.plos.org
Identification of voltage-gated sodium channel NaV1. 7 inhibitors for chronic pain
therapeutic development is an area of vigorous pursuit. In an effort to identify more potent …
therapeutic development is an area of vigorous pursuit. In an effort to identify more potent …
Pain-related toxins in scorpion and spider venoms: a face to face with ion channels
S Diochot - Journal of venomous animals and toxins including …, 2021 - SciELO Brasil
Pain is a common symptom induced during envenomation by spiders and scorpions. Toxins
isolated from their venom have become essential tools for studying the functioning and …
isolated from their venom have become essential tools for studying the functioning and …
Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain
Chemical transfection is broadly used to transiently transfect mammalian cells, although
often associated with cellular stress and membrane instability, which imposes challenges for …
often associated with cellular stress and membrane instability, which imposes challenges for …