Chemokines are a family of cytokines that orchestrate the migration and positioning of
immune cells within tissues and are critical for the function of the immune system. CCR2 …

Macrophages, which are abundant in the tumour microenvironment, enhance malignancy.
At metastatic sites, a distinct population of metastasis-associated macrophages promotes …

A low response rate, acquired resistance and severe side effects have limited the clinical
outcomes of immune checkpoint therapy. Here, we show that combining cancer …

Hepatocellular carcinoma, a deadly disease, commonly arises in the setting of chronic
inflammation. CC motif chemokine ligand 2 (CCL2/MCP1), a chemokine that recruits CCR2 …

Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs)
inhibit anti-tumor immune responses and facilitate tumor growth. Precursors for these …

Altering the immunosuppressive microenvironment that exists within a tumor will likely be
necessary for cancer vaccines to trigger an effective antitumor response. Monocyte …

Primary graft dysfunction (PGD) is the predominant cause of early graft loss following lung
transplantation. We recently demonstrated that donor pulmonary intravascular nonclassical …

Malignant pleural effusion (MPE) is the lethal consequence of various human cancers
metastatic to the pleural cavity. However, the mechanisms responsible for the development …

Mast cells (MCs) have been identified in various tumors; however, the role of these cells in
tumorigenesis remains controversial. Here, we quantified MCs in human and murine …

The role of chemokines in the pathogenesis of lung cancer has been increasingly
appreciated. Monocyte chemoattractant protein–1 (MCP-1, also known as CCL2) is secreted …