Functional roles of chemokine receptor CCR2 and its ligands in liver disease
S She, L Ren, P Chen, M Wang, D Chen… - Frontiers in …, 2022 - frontiersin.org
Chemokines are a family of cytokines that orchestrate the migration and positioning of
immune cells within tissues and are critical for the function of the immune system. CCR2 …
immune cells within tissues and are critical for the function of the immune system. CCR2 …
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
BZ Qian, J Li, H Zhang, T Kitamura, J Zhang… - Nature, 2011 - nature.com
Macrophages, which are abundant in the tumour microenvironment, enhance malignancy.
At metastatic sites, a distinct population of metastasis-associated macrophages promotes …
At metastatic sites, a distinct population of metastasis-associated macrophages promotes …
Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators
A low response rate, acquired resistance and severe side effects have limited the clinical
outcomes of immune checkpoint therapy. Here, we show that combining cancer …
outcomes of immune checkpoint therapy. Here, we show that combining cancer …
Blocking the CCL2–CCR2 axis using CCL2-neutralizing antibody is an effective therapy for hepatocellular cancer in a mouse model
Hepatocellular carcinoma, a deadly disease, commonly arises in the setting of chronic
inflammation. CC motif chemokine ligand 2 (CCL2/MCP1), a chemokine that recruits CCR2 …
inflammation. CC motif chemokine ligand 2 (CCL2/MCP1), a chemokine that recruits CCR2 …
Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy
Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs)
inhibit anti-tumor immune responses and facilitate tumor growth. Precursors for these …
inhibit anti-tumor immune responses and facilitate tumor growth. Precursors for these …
CCL2 blockade augments cancer immunotherapy
ZG Fridlender, G Buchlis, V Kapoor, G Cheng, J Sun… - Cancer research, 2010 - AACR
Altering the immunosuppressive microenvironment that exists within a tumor will likely be
necessary for cancer vaccines to trigger an effective antitumor response. Monocyte …
necessary for cancer vaccines to trigger an effective antitumor response. Monocyte …
[HTML][HTML] Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte …
C Kurihara, E Lecuona, Q Wu, W Yang… - JCI insight, 2021 - ncbi.nlm.nih.gov
Primary graft dysfunction (PGD) is the predominant cause of early graft loss following lung
transplantation. We recently demonstrated that donor pulmonary intravascular nonclassical …
transplantation. We recently demonstrated that donor pulmonary intravascular nonclassical …
Mutant KRAS promotes malignant pleural effusion formation
T Agalioti, AD Giannou, AC Krontira… - Nature …, 2017 - nature.com
Malignant pleural effusion (MPE) is the lethal consequence of various human cancers
metastatic to the pleural cavity. However, the mechanisms responsible for the development …
metastatic to the pleural cavity. However, the mechanisms responsible for the development …
Mast cells mediate malignant pleural effusion formation
AD Giannou, A Marazioti, M Spella… - The Journal of …, 2015 - Am Soc Clin Investig
Mast cells (MCs) have been identified in various tumors; however, the role of these cells in
tumorigenesis remains controversial. Here, we quantified MCs in human and murine …
tumorigenesis remains controversial. Here, we quantified MCs in human and murine …
Monocyte Chemoattractant Protein–1 Blockade Inhibits Lung Cancer Tumor Growth by Altering Macrophage Phenotype and Activating CD8+ Cells
ZG Fridlender, V Kapoor, G Buchlis… - American journal of …, 2011 - atsjournals.org
The role of chemokines in the pathogenesis of lung cancer has been increasingly
appreciated. Monocyte chemoattractant protein–1 (MCP-1, also known as CCL2) is secreted …
appreciated. Monocyte chemoattractant protein–1 (MCP-1, also known as CCL2) is secreted …