The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

Living organisms depend on timely and organized interactions between proteins linked in
interactomes of high complexity. The recent increased precision by which protein …

Transcription-coupled DNA repair removes bulky DNA lesions from the genome, and
protects cells against ultraviolet (UV) irradiation. Transcription-coupled DNA repair begins …

▪ Abstract Sorting of transmembrane proteins to endosomes and lysosomes is mediated by
signals present within the cytosolic domains of the proteins. Most signals consist of short …

Furin catalyses a simple biochemical reaction—the proteolytic maturation of proprotein
substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and …

Lysosomes are composed of soluble and transmembrane proteins that are targeted to
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …

The sequencing of complete genomes provides a list that includes the proteins responsible
for cellular regulation. However, this does not immediately reveal what these proteins do …

The two mannose 6-phosphate (M6P) receptors were identified because of their ability to
bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the …

The sorting of proteins into the inner vesicles of multivesicular bodies is required for many
key cellular processes, which range from the downregulation of activated signalling …

fEndosome-to-Golgi retrieval of the mannose 6-phosphate receptor (MPR) is required for
lysosome biogenesis. Currently, this pathway is poorly understood. Analyses in yeast …