Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens

ML Newby, JD Allen, M Crispin - Biotechnology Advances, 2024 - Elsevier
A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …

[HTML][HTML] Vaccines for Respiratory Viruses—COVID and Beyond

K Rajanala, AK Upadhyay - Vaccines, 2024 - mdpi.com
The COVID-19 (coronavirus disease 2019) pandemic had an extensive impact on global
morbidity and mortality. Several other common respiratory viruses, such as the influenza …

Cost‐effectiveness analysis of cell‐based versus egg‐based quadrivalent influenza vaccines in the pediatric population in Taiwan

CY Chi, MF Cheng, K Ko, JF Mould… - Journal of Medical …, 2024 - Wiley Online Library
Cell‐based influenza vaccines avoid egg‐adaptive mutations, potentially improving vaccine
effectiveness. We assessed the one‐season cost‐effectiveness of cell‐based quadrivalent …

Advances in protein subunit vaccines against H1N1/09 influenza

Y Zhang, J Gao, W Xu, X Huo, J Wang, Y Xu… - Frontiers in …, 2024 - frontiersin.org
The A/H1N1pdm09 influenza virus, which caused the 2009 pandemic, has since become a
recurring strain in seasonal influenza outbreaks. Given the ongoing threat of influenza …

The economic rationale for cell-based influenza vaccines in children and adults: A review of cost-effectiveness analyses

D Fisman, N Giglio, MJ Levin, VH Nguyen… - Human Vaccines & …, 2024 - Taylor & Francis
Seasonal influenza significantly affects both health and economic costs in children and
adults. This narrative review summarizes published cost-effectiveness analyses (CEAs) of …

Novel Influenza Vaccines: From Research and Development (R&D) Challenges to Regulatory Responses

X He, T Zhang, S Huan, Y Yang - Vaccines, 2023 - mdpi.com
Influenza vaccines faced significant challenges in achieving sufficient protective efficacy and
production efficiency in the past. In recent decades, novel influenza vaccines, characterized …

Cost-effectiveness of cell-based influenza vaccine in France

G Gavazzi, M Paccalin, Q Berkovitch… - Expert Review of …, 2024 - Taylor & Francis
ABSTRACT Objectives Annually in France, influenza results in over one million GP
consultations, around 20,000 hospitalizations, and approximately 9,000 deaths. This study …

Influenza burden averted with a cell-based quadrivalent seasonal influenza vaccine compared with egg-based quadrivalent seasonal influenza vaccine

I McGovern, A Taylor, A Sardesai… - Expert Review of …, 2024 - Taylor & Francis
Background Cell-based quadrivalent inactivated influenza vaccines (IIV4c) avoid egg-
adaptive mutations found in egg-based production, improving vaccine effectiveness (VE) …

Differential Induction of Interferon-Stimulated Genes by Cell-Based Versus Egg-Based Quadrivalent Influenza Vaccines in Children During the 2018–2019 Season

JM Martin, K Moehling Geffel, MA Ortiz… - The Journal of …, 2024 - academic.oup.com
Background Cell-based quadrivalent-inactivated influenza vaccine has been shown to have
higher vaccine effectiveness than traditional egg-based quadrivalent-inactivated influenza …

The potential benefits of delaying seasonal influenza vaccine selections for the Northern Hemisphere: a retrospective modeling study in the United States

K Lee, KV Williams, JA Englund… - The Journal of …, 2023 - academic.oup.com
Background Antigenic similarity between vaccine viruses and circulating viruses is crucial
for achieving high vaccine effectiveness against seasonal influenza. New non-egg-based …