The large tumor antigen (T antigen) encoded by simian virus 40 is an amazing molecular
machine because it orchestrates viral infection by modulating multiple fundamental viral and …

During eukaryotic DNA replication, Pol α-primase generates primers at replication origins to
start leading-strand synthesis and every few hundred nucleotides during discontinuous …

Replication protein A (RPA) is a heterotrimeric protein complex and the main single-
stranded DNA (ssDNA)-binding protein in eukaryotes. RPA has key functions in most of the …

The CST–Polα/primase complex is essential for telomere maintenance and functions to
counteract resection at double-strand breaks. We report a 4.6-Å resolution cryo-EM structure …

Replication protein A (RPA) is the main eukaryotic ssDNA-binding protein with essential
roles in DNA replication, recombination, and repair. RPA maintains the DNA as single …

Natural tetracyclic diterpenoid aphidicolin is a potent and specific inhibitor of B-family DNA
polymerases, haltering replication and possessing a strong antimitotic activity in human …

A dynamic multi-protein assembly known as the replisome is responsible for DNA synthesis
in eukaryotic cells. In yeast, the hub protein Ctf4 bridges DNA helicase and DNA polymerase …

In eukaryotic DNA replication, short RNA-DNA hybrid primers synthesized by primase-DNA
polymerase α (Prim-Pol α) are needed to start DNA replication by the replicative DNA …

Maintenance of genomic stability in proliferating cells depends on a network of proteins that
coordinate chromosomal replication with DNA damage responses. Human DNA helicase B …

The initiation of DNA synthesis during replication of the human genome is accomplished
primarily by the DNA polymerase α-primase complex, which makes the RNA-DNA primers …