Lipid rafts: controversies resolved, mysteries remain
The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …
biological membranes into domains of distinct structures, compositions, and functions. This …
[HTML][HTML] Membrane homeostasis beyond fluidity: control of membrane compressibility
Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …
compartmentalize biochemistry. They are actively remodeled in response to physical and …
[HTML][HTML] Structural determinants and functional consequences of protein affinity for membrane rafts
Eukaryotic plasma membranes are compartmentalized into functional lateral domains,
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …
Generation of extracellular morphogen gradients: the case for diffusion
KS Stapornwongkul, JP Vincent - Nature Reviews Genetics, 2021 - nature.com
Cells within developing tissues rely on morphogens to assess positional information.
Passive diffusion is the most parsimonious transport model for long-range morphogen …
Passive diffusion is the most parsimonious transport model for long-range morphogen …
Membrane lipid nanodomains
Lipid membranes can spontaneously organize their components into domains of different
sizes and properties. The organization of membrane lipids into nanodomains might …
sizes and properties. The organization of membrane lipids into nanodomains might …
[HTML][HTML] Regulation of lipid saturation without sensing membrane fluidity
Cells maintain membrane fluidity by regulating lipid saturation, but the molecular
mechanisms of this homeoviscous adaptation remain poorly understood. We have …
mechanisms of this homeoviscous adaptation remain poorly understood. We have …
[HTML][HTML] Mechanical properties of plasma membrane vesicles correlate with lipid order, viscosity and cell density
Regulation of plasma membrane curvature and composition governs essential cellular
processes. The material property of bending rigidity describes the energetic cost of …
processes. The material property of bending rigidity describes the energetic cost of …
[HTML][HTML] Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer
Immune cells identify and destroy tumors by recognizing cellular traits indicative of
oncogenic transformation. In this study, we found that myocardin-related transcription factors …
oncogenic transformation. In this study, we found that myocardin-related transcription factors …
[HTML][HTML] T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles
PF Céspedes, A Jainarayanan… - Nature …, 2022 - nature.com
The immunological synapse is a molecular hub that facilitates the delivery of three activation
signals, namely antigen, costimulation/corepression and cytokines, from antigen-presenting …
signals, namely antigen, costimulation/corepression and cytokines, from antigen-presenting …
Single-vesicle assays using liposomes and cell-derived vesicles: from modeling complex membrane processes to synthetic biology and biomedical applications
The plasma membrane is of central importance for defining the closed volume of cells in
contradistinction to the extracellular environment. The plasma membrane not only serves as …
contradistinction to the extracellular environment. The plasma membrane not only serves as …