Lipid rafts: controversies resolved, mysteries remain

I Levental, KR Levental, FA Heberle - Trends in cell biology, 2020 - cell.com
The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …

[HTML][HTML] Membrane homeostasis beyond fluidity: control of membrane compressibility

MF Renne, R Ernst - Trends in Biochemical Sciences, 2023 - cell.com
Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …

[HTML][HTML] Structural determinants and functional consequences of protein affinity for membrane rafts

JH Lorent, B Diaz-Rohrer, X Lin, K Spring… - Nature …, 2017 - nature.com
Eukaryotic plasma membranes are compartmentalized into functional lateral domains,
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …

Generation of extracellular morphogen gradients: the case for diffusion

KS Stapornwongkul, JP Vincent - Nature Reviews Genetics, 2021 - nature.com
Cells within developing tissues rely on morphogens to assess positional information.
Passive diffusion is the most parsimonious transport model for long-range morphogen …

Membrane lipid nanodomains

M Cebecauer, M Amaro, P Jurkiewicz… - Chemical …, 2018 - ACS Publications
Lipid membranes can spontaneously organize their components into domains of different
sizes and properties. The organization of membrane lipids into nanodomains might …

[HTML][HTML] Regulation of lipid saturation without sensing membrane fluidity

S Ballweg, E Sezgin, M Doktorova, R Covino… - Nature …, 2020 - nature.com
Cells maintain membrane fluidity by regulating lipid saturation, but the molecular
mechanisms of this homeoviscous adaptation remain poorly understood. We have …

[HTML][HTML] Mechanical properties of plasma membrane vesicles correlate with lipid order, viscosity and cell density

J Steinkühler, E Sezgin, I Urbančič, C Eggeling… - Communications …, 2019 - nature.com
Regulation of plasma membrane curvature and composition governs essential cellular
processes. The material property of bending rigidity describes the energetic cost of …

[HTML][HTML] Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer

M Tello-Lafoz, K Srpan, EE Sanchez, J Hu, J Remsik… - Immunity, 2021 - cell.com
Immune cells identify and destroy tumors by recognizing cellular traits indicative of
oncogenic transformation. In this study, we found that myocardin-related transcription factors …

[HTML][HTML] T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles

PF Céspedes, A Jainarayanan… - Nature …, 2022 - nature.com
The immunological synapse is a molecular hub that facilitates the delivery of three activation
signals, namely antigen, costimulation/corepression and cytokines, from antigen-presenting …

Single-vesicle assays using liposomes and cell-derived vesicles: from modeling complex membrane processes to synthetic biology and biomedical applications

H Pick, AC Alves, H Vogel - Chemical reviews, 2018 - ACS Publications
The plasma membrane is of central importance for defining the closed volume of cells in
contradistinction to the extracellular environment. The plasma membrane not only serves as …