Invited review: the preterm pig as a model in pediatric gastroenterology

PT Sangild, T Thymann, M Schmidt… - Journal of animal …, 2013 - academic.oup.com
At birth, the newborn mammal undergoes a transition from a sterile uterine environment with
a constant nutrient supply, to a microbe-rich environment with intermittent oral intake of …

Emerging biomarkers for prediction and early diagnosis of necrotizing enterocolitis in the era of metabolomics and proteomics

E Agakidou, C Agakidis, H Gika, K Sarafidis - Frontiers in Pediatrics, 2020 - frontiersin.org
Necrotizing Enterocolitis (NEC) is a catastrophic disease affecting predominantly premature
infants and is characterized by high mortality and serious long-term consequences …

Recent advances in the use of Sus scrofa (pig) as a model system for proteomic studies

N Verma, AW Rettenmeier, S Schmitz‐Spanke - Proteomics, 2011 - Wiley Online Library
Of the numerous animal models available for proteomic studies only a small number have
been successfully used in understanding human biology. To date, rodents have been widely …

Farm animal proteomics—a review

E Bendixen, M Danielsen, K Hollung, E Gianazza… - Journal of …, 2011 - Elsevier
In agricultural sciences as in all other areas of life science, the implementation of proteomics
and other post-genomic tools is an important step towards more detailed understanding of …

Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis

Y Liu, DQ Tran, NY Fatheree… - American Journal of …, 2014 - journals.physiology.org
Necrotizing enterocolitis (NEC) is an inflammatory disease with evidence of increased
production of proinflammatory cytokines in the intestinal mucosa. Lactobacillus reuteri DSM …

Biomarkers for infants at risk for necrotizing enterocolitis: clues to prevention?

C Young, R Sharma, M Handfield, V Mai, J Neu - Pediatric research, 2009 - nature.com
Necrotizing enterocolitis (NEC) is the most common severe gastrointestinal emergency that
affects premature newborns. This disease often has a rapid onset with few, if any …

Metabolomic and proteomic analysis of serum from preterm infants with necrotising entercolitis and late-onset sepsis

CJ Stewart, A Nelson, A Treumann, T Skeath… - Pediatric …, 2016 - nature.com
Background: Necrotising enterocolitis (NEC) and late-onset sepsis (LOS) are the leading
causes of death among preterm infants in the developed world. This study aimed to explore …

Pig proteomics: a review of a species in the crossroad between biomedical and food sciences

AM de Almeida, E Bendixen - Journal of Proteomics, 2012 - Elsevier
The pig (Sus scrofa) is one of the most important animal species used for meat production
worldwide, playing a fundamental role in numerous cultures from Southern Europe to the …

Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis

H Wang, G Wu, HJ Park, PP Jiang, WH Sit… - Chinese medicine, 2012 - Springer
Background The hepatoprotective potential of Phellinus linteus polysaccharide (PLP)
extracts has been described. However, the molecular mechanism of PLP for the inhibition of …

Marked methylation changes in intestinal genes during the perinatal period of preterm neonates

F Gao, J Zhang, P Jiang, D Gong, JW Wang, Y Xia… - BMC genomics, 2014 - Springer
Background The serious feeding-and microbiota-associated intestinal disease, necrotizing
enterocolitis (NEC), occurs mainly in infants born prematurely (5-10% of all newborns) and …