Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
Synthesis and function of 3-phosphorylated inositol lipids
B Vanhaesebroeck, SJ Leevers… - Annual review of …, 2001 - annualreviews.org
▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …
[HTML][HTML] Essential role of phosphoinositide metabolism in synaptic vesicle recycling
Growing evidence suggests that phosphoinositides play an important role in membrane
traffic. A polyphosphoinositide phosphatase, synaptojanin 1, was identified as a major …
traffic. A polyphosphoinositide phosphatase, synaptojanin 1, was identified as a major …
A presynaptic inositol-5-phosphatase
PS McPherson, EP Garcia, VI Slepnev, C David… - Nature, 1996 - nature.com
SYNAPTOJANIN is a nerve terminal protein of relative molecular mass 145,000 which
appears to participate with dynamin in synaptic vesicle recycling1, 2. The central region of …
appears to participate with dynamin in synaptic vesicle recycling1, 2. The central region of …
An essential role for a phospholipid transfer protein in yeast Golgi function
PROGRESSION of proteins through the secretory pathway of eukaryotic cells involves a
continuous rearrangement of macromolecular structures made up of proteins and …
continuous rearrangement of macromolecular structures made up of proteins and …
[HTML][HTML] SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases
S Guo, LE Stolz, SM Lemrow, JD York - Journal of Biological Chemistry, 1999 - ASBMB
The SAC1 gene product has been implicated in the regulation of actin cytoskeleton,
secretion from the Golgi, and microsomal ATP transport; yet its function is unknown. Within …
secretion from the Golgi, and microsomal ATP transport; yet its function is unknown. Within …
Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae
T Strahl, J Thorner - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2007 - Elsevier
It is now well appreciated that derivatives of phosphatidylinositol (PtdIns) are key regulators
of many cellular processes in eukaryotes. Of particular interest are phosphoinositides (mono …
of many cellular processes in eukaryotes. Of particular interest are phosphoinositides (mono …
Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae
In fungi and many other organisms, a thick outer cell wall is responsible for determining the
shape of the cell and for maintaining its integrity. The budding yeast Saccharomyces …
shape of the cell and for maintaining its integrity. The budding yeast Saccharomyces …
Phosphoinositide signaling and the regulation of membrane trafficking in yeast
Phosphoinositides are key regulators of diverse cellular processes in eukaryotic cells.
Genetic studies in yeast have advanced our understanding of how phosphoinositide …
Genetic studies in yeast have advanced our understanding of how phosphoinositide …
Phosphoinositides in constitutive membrane traffic
MG Roth - Physiological reviews, 2004 - journals.physiology.org
Proteins that make, consume, and bind to phosphoinositides are important for constitutive
membrane traffic. Different phosphoinositides are concentrated in different parts of the …
membrane traffic. Different phosphoinositides are concentrated in different parts of the …