Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

A Galano, RJ Reiter - Journal of Pineal Research, 2018 - Wiley Online Library
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases

S Losada-Barreiro, C Bravo-Diaz - European journal of medicinal chemistry, 2017 - Elsevier
The oxidation of bioorganic materials by air and, particularly, the oxidative stress involved in
the cell loss and other pathologies associated with neurodegenerative diseases (NDs) are …

Black phosphorus nanosheets as a neuroprotective nanomedicine for neurodegenerative disorder therapy

W Chen, J Ouyang, X Yi, Y Xu, C Niu… - Advanced …, 2018 - Wiley Online Library
Transition‐metal dyshomeostasis is recognized as a critical pathogenic factor at the onset
and progression of neurodegenerative disorder (ND). Excess transition‐metal ions such as …

Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease

Q Li, H Yang, Y Chen, H Sun - European journal of medicinal chemistry, 2017 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders with
notable factor of dysfunction in cholinergic system. Low ACh level can be observed in the …

Computational strategies for predicting free radical scavengers' protection against oxidative stress: where are we and what might follow?

A Galano, J Raúl Alvarez‐Idaboy - International Journal of …, 2019 - Wiley Online Library
Oxidative stress, which is frequently induced by an overproduction of free radicals (FR),
poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a …

Multitarget therapeutic strategies for Alzheimer's disease: Review on emerging target combinations

S Maramai, M Benchekroun, MT Gabr… - BioMed Research …, 2020 - Wiley Online Library
Neurodegenerative diseases represent nowadays one of the major health problems.
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not …

Curcumin in health and diseases: Alzheimer's disease and curcumin analogues, derivatives, and hybrids

E Chainoglou, D Hadjipavlou-Litina - International journal of molecular …, 2020 - mdpi.com
Worldwide, Alzheimer's disease (AD) is the most common neurodegenerative multifactorial
disease influencing the elderly population. Nowadays, several medications, among them …

[HTML][HTML] Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?

R Franco, A Cedazo-Minguez - Frontiers in pharmacology, 2014 - frontiersin.org
Peering into the field of Alzheimer's disease (AD), the outsider realizes that many of the
therapeutic strategies tested (in animal models) have been successful. One also may notice …

Neuroprotective effects of bioavailable polyphenol-derived metabolites against oxidative stress-induced cytotoxicity in human neuroblastoma SH-SY5Y cells

A González-Sarrías, MA Núñez-Sánchez… - Journal of agricultural …, 2017 - ACS Publications
Oxidative stress is involved in cell death in neurodegenerative diseases. Dietary
polyphenols can exert health benefits, but their direct effects on neuronal cells are debatable …

Dancing with reactive oxygen species generation and elimination in nanotheranostics for disease treatment

Z Zhou, K Ni, H Deng, X Chen - Advanced drug delivery reviews, 2020 - Elsevier
Reactive oxygen species (ROS) play important roles in cell signaling and tissue
homeostasis, in which the level of ROS is critical through the equilibrium between ROS …