Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

Myeloperoxidase (MPO) is a heme-containing peroxidase expressed mainly in neutrophils
and to a lesser degree in monocytes. In the presence of hydrogen peroxide and halides …

Summary Using untargeted metabolomics (n= 1,162 subjects), the plasma metabolite (m/z=
265.1188) phenylacetylglutamine (PAGln) was discovered and then shown in an …

Rheumatoid arthritis (RA) is a systemic auto-immune disease principally effecting synovial
joints. RA is characterized by immune cell infiltration in the joint. The presence of …

Myeloperoxidase (MPO) is a member of the superfamily of heme peroxidases that is mainly
expressed in neutrophils and monocytes. MPO-derived reactive species play a key role in …

Summary Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite,
both enhances atherosclerosis in animal models and is associated with cardiovascular risks …

Significance: The release of myeloperoxidase (MPO) by activated leukocytes is critical in
innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong …

Chronic kidney disease (CKD) induces modifications in lipid and lipoprotein metabolism and
homeostasis. These modifications can promote, modulate and/or accelerate CKD and …

BACKGROUND. l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis
in mice via gut microbiota–dependent formation of trimethylamine (TMA) and trimethylamine …

Patients with chronic kidney disease (CKD) are at an increased risk of premature mortality,
mainly from cardiovascular causes. The association between CKD on hemodialysis and …